Physical exercise enhanced the sensory function in the knee joint with aging and disuse

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The purpose of study is to analyze whether physical exercise enhanced the neural function in the knee joint with aging and disuse. Exercised rats showed a quantitative increase neurotrophin immunostaining that was mostly evident in the spinal cords. In biochemical assay, exercise increases selectively expression of neurotrophins and receptors mRNA in the lumber spinal cord in senescence. These results suggest that exercise enhanced neurotrophins and their receptors by physiological process that it is endogenous in the lumber spinal cords which innervate the knee joints.