PHIP-X: efficient hyperpolarization of small molecules in solution using proton exchange
PHIP-X:利用质子交换实现溶液中小分子的高效超极化
基本信息
- 批准号:537840895
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The hyperpolarization of nuclear spins is an extremely interesting field of research that has developed rapidly in recent years. So far, however, there is no method that allows molecules to be polarized easily, quickly, and generically in solution; all known hyperpolarization techniques are restricted to particular molecules or states of matter (e.g., gases, solids, unsaturated or Ir-exchanging compounds). A comparatively broadly applicable method for the liquid state would be extremely valuable, for example, for high-resolution magnetic resonance spectroscopy. An interesting approach to address this problem is the exchange of polarized protons. That this method works in principle has already been shown - but only with quite low polarizations, or after relatively slow polarizations (DNP). Recently, we have introduced a new method that allows exchanging protons to be highly polarized within a few seconds. Here, the spin order of parahydrogen is transferred from a transfer molecule to a third molecule via proton exchange. This method combines the simplicity and high polarization yields of hydrogenative parahydrogen induced polarization (PHIP) with the broad applicability of polarization transfer via proton exchange. The goal of this proposal is to explore and optimize this method with respect to chemical and biological applications. For this purpose, we first want to analyze the method in detail, and then apply the gained insights experimentally.
核自旋的超极化是近年来发展迅速的一个非常有趣的研究领域。然而,到目前为止,还没有允许分子在溶液中容易地、快速地和一般地极化的方法;所有已知的超极化技术都限于特定的分子或物质状态(例如,气体、固体、不饱和或Ir交换化合物)。一个相对广泛适用于液态的方法将是非常有价值的,例如,对于高分辨率磁共振光谱学。解决这个问题的一个有趣的方法是极化质子的交换。这种方法在原理上是可行的,但只有在非常低的偏振下,或者在相对慢的偏振(DNP)之后。最近,我们引入了一种新方法,可以在几秒钟内使交换质子高度极化。在这里,仲氢的自旋序通过质子交换从转移分子转移到第三分子。该方法结合了氢化仲氢诱导极化(PHIP)的简单性和高极化产率与通过质子交换的极化转移的广泛适用性。该提案的目标是探索和优化这种方法在化学和生物学应用方面的应用。为此,我们首先要详细分析该方法,然后通过实验应用所获得的见解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Jan-Bernd Hövener其他文献
Professor Dr. Jan-Bernd Hövener的其他文献
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{{ truncateString('Professor Dr. Jan-Bernd Hövener', 18)}}的其他基金
Long-lived hyperpolarized molecules for magnetic resonance produced using parahydrogen
使用仲氢生产用于磁共振的长寿命超极化分子
- 批准号:
409904993 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Research Grants
Metabolic and Molecular MRI using Hyperpolarized Tracers
使用超极化示踪剂的代谢和分子 MRI
- 批准号:
246504068 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Independent Junior Research Groups
Molekulare Bildgebung mit 13C-hyperpolarisierten Tracern zur Differenzierung von abnormalem Gewebe in vivo
使用 13C 超极化示踪剂进行分子成像以区分体内异常组织
- 批准号:
194802162 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Research Grants
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