Formation of a healthy colonic environment under the control of protein nutrition during the weaning period

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To determine whether protein affects formation of the colonic environment during the weaning period, we examined the change in colonic microbiota and fermentation in weaning rats fed different proteins. Colonic microbiota, colonized by soy protein isolate during the weaning period, were stable and produced high amounts of butyrate. The same phenomenon was also observed in obese mice, suggesting that unique colonic microbiota were formed by the administration of soy protein isolate during the weaning period. In addition, the administration of soy protein isolate may be involved in the suppression of fat accumulation due to the unique microbiota. Taken together, we found that the administration of appropriate protein during the weaning period established a healthy colonic environment.