Studies on high carbohydrate diet-induced transcription factors.

SHARP-1和SHARP-2都是高碳水化合物饮食诱导的转录因子。我们假设这些因素通过胰岛素抑制肝细胞生成而参与血糖水平的降低。在这项研究中，控制这些基因的表达的机制进行了分析。结果表明，胰岛素诱导SHARP-1 mRNA的水平，SHARP-1而不是SHARP-2的基因表达受AMP激活的蛋白激酶调节，并且大豆异黄酮和绿色茶多酚EGCG与胰岛素一样快速诱导这些基因的表达。

Both SHARP-1 and SHARP-2 are high carbohydrate diet-induced transcription factors. We assume that these factors are involved in the lowering of blood glucose level via a suppression of hepatic gluconeogenesis by insulin. In this study, a mechanism(s) controlling expressions of these genes was analyzed. As the results, we showed that insulin induced the level of SHARP-1 mRNA, gene expression of SHARP-1 but not SHARP-2 was regulated by AMP-activated protei kinase, and that genistein, a soybean isoflavone, and EGCG, a green tea polyphenol, rapidly induced these gene expressions as well as insulin.