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Induction Mechanism of Genomic Instability Induced Independent of DNA Damage and the Implication on Carcinogenesis

Induction Mechanism of Genomic Instability Induced Independent of DNA Damage and the Implication on Carcinogenesis
独立于 DNA 损伤的基因组不稳定性的诱导机制及其对癌发生的影响
批准号:
21510054
负责人:
NUNOSHIBA Tatsuo
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Hydroquinone(HQ), which is the metabolite of the non-mutagenic carcinogen, benzene, induced loss of heterozygosity(LOH), through chromosomal mis-segrigation. HQ interacted to tubulin, interfered valance between polymerization/dissociation during microtubule formation, and activated Hog1-Swe1 morphogenesis checkpoint, suggesting that LOH induced by HQ is implicated in these characteristics of HQ. By using the LOH detection system, various iron beams with different LET also induced LOH through homologous recombination.
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Genetic Instability Inducers in Saccharomyces cerevisiae : An Ames-negative carcinogen, Phenyl hydroquinone(PHQ)
酿酒酵母中的遗传不稳定诱导物:Ames 阴性致癌物,苯基氢醌 (PHQ)
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [山崎彩夏, Juri Suzuki, Hidetoshi Kurotori, Shohei Takeda, 武田庄平, 武田庄平, Nunoshiba T]
通讯作者: Nunoshiba T
細胞周期チェックポイントと染色体異数性誘発
细胞周期检查点和染色体非整倍体诱导
DOI: --
发表时间: 2009
期刊: 放射線生物研究
影响因子: --
作者: [山本歩, 布柴達男]
通讯作者: 布柴達男
Genetic Instability Inducers in Saccharomyces cerevisiae : An Amesnegative carcinogen, Phenyl hydroquinone(PHQ)
酿酒酵母中的遗传不稳定诱导物:Ames 阴性致癌物,苯基氢醌 (PHQ)
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [山崎彩夏, 武田庄平, 菅原広, 伊沢学, 武田和浩, 飯田雄一, 三浦史順, 一條裕也, Nunoshiba T]
通讯作者: Nunoshiba T
21
    Elucidation of mechanisms for genomic integrity through establishing novel tools for genetic analysis in Thermus thermophilus.
    • 批准号:
      26340029
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2014
    • 负责人:
      NUNOSHIBA Tatsuo
    • 依托单位:
    Induction of Genomic Instability Induced by Chromosome Mis-segregation and the Implication on Carcinogenesis
    • 批准号:
      19510054
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2007
    • 负责人:
      NUNOSHIBA Tatsuo
    • 依托单位:
    The sanitizing systems for endogenous nucleotide lesions, and their roles on spontaneous mutagenesis
    • 批准号:
      15510041
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.11万
    • 财政年份:
      2003
    • 负责人:
      NUNOSHIBA Tatsuo
    • 依托单位:
    海外基金