Computational Science Study of Similarities and Differences between bacterial Ice-Nucleating Protein and Insect Anti-Freeze Protein

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In this project, similarities and differences between bacterial ice-nucleating protein(INP) and insect antifreeze protein(AFP) were studied using both computer simulation and ice crystal growth experiment. The results suggested that as a similarity, both INP and AFP are the proteins that significantly alter the anisotropy in ice crystal growth rate. The results also suggested that as a difference, INP binds selectively to ice basal planes, whereas AFP binds to both ice basal and prismatic planes. In conclusion, both INP and AFP are ice-binding proteins. However, the structure of INP is thought to be different from the structure of AFP.