Synthesis and characterization of composite metal complexes aiming at regulations of genetic information

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We have synthesized various mixed ligand and multinuclear metal complexes and analyzed the DNA binding structures、evaluating the DNA binding affinity and the cleavage activity. The results indicated that the composite metal complexes strengthened efficiently the interaction with DNA and enhanced the cleavage activity. In addition、some of the complexes have been found to show a new type of anticancer activity. We have also synthesized new DNA metal complex conjugates and succeeded in developing an efficient technique for the detection of DNA SNPs by making use of protein splicing reactions.