Novel Binding Structures and Reactions of Metal Complexes of Some Combired Ligands

在本研究中，对1） bleomycin （Blm）和deglycopepromycin （Dpe）的金属复合体， 2）acridine-polyamin， 3）含有组织肽的组蛋白， 4）vigen-porphyrin被调查了新颖的结合结构和DNA反应。结果如下：1） Fe（III）Blm绑定DNA与两个不同的方向和ON-Fe中的NO（II）Blm确实处于原位，运动在DNA上受到严重限制。低自旋Fe（III）Dpe改变了DNA上的高自旋物种。Cu（II）Dpe cannot bind stereo specifically on DNA.2） Some platinum complexes of acridine-polyamines显示更多intense cytoxicity than cis-platin。对于铜（II）复合体，它是由DNA-纤维ESR光谱仪发现的，其中一些复合体的协调活力在房间温度下移动明显。3）L-组氨酸形式的铜（II）复合体在DNA的聚合立体声上结合在一起。Cu（II） complexes of X-D2aa-Gly-His（X-D2aa-D2=Gly， Lys， Arg） binds in the minor groove of B-form DNA。序列特定的清除反应由相应的Ni（III）复合体在一种绑定结构中被讨论。4） Cu（II）复合体的中间替代四viologen porphyrin绑定DNA如此强大，以至于它桥接了双重健康DNA，当单替代性卟啉复合体是非常不稳定的，因为它在DNA上的分解可以形成铜（二）从Porphyrin衍生出的未知片段的复合体，上述结果已在多项期刊中发表或在国际和领域的综合体中展示在研究报告中。

In this study, metal complexes of 1) bleomycin (Blm) and deglycopepromycin (Dpe), 2) acridine-polyamin, 3) histidine-containing peptides, 4) vilogen-porphyrin have been investigated on the novel binding structures and the reactions on DNA. The results are listed below.1) Fe(III)Blm binds DNA with two different orientations and NO in ON-Fe(II)Blm is held rigidly in place and the motion is severely restricted on the DNA. The low-spin Fe(III)Dpe changes irreversibly to high-spin species on DNA. Cu(II)Dpe cannot bind stereo specifically on DNA.2) Some platinum complexes of acridine-polyamines show more intense cytotoxicity than cis-platin. For the copper(II) complexes, it was found by DNA-fiber ESR spectroscopy that the coordinating moiety of some of the complexes is moving vigorously at room temperature.3) Cu(II) complex of L-histidine forms an aggregate stereospecifically bound on DNA. Cu(II) complexes of XィイD2aaィエD2-Gly-His (XィイD2aaィエD2=Gly, Lys, Arg) binds in the minor groove of B-form DNA. The sequence specific cleaving reactions by corresponding Ni(III) complexes were discussed in terms such a binding structure.4) Cu(II) complex of a meso-substituted tetra-viologen porphyrin binds DNA so strongly that it bridges double helical DNA, while the mono-substituted porphyrin complex is so unstable that it decomposes on DNA to form a Cu(II) complex with the unknown fragment derived from the porphyrin.The above results have been published in several journals or presented at the international and domestic symposiums as shown in the Research Report.