Development of Iridium-Catalyzed Highly Selective Organic Synthesis

铱催化的合成反应相对于钴、铑、铼和钯催化的合成反应发展较少。在本项目中，我们开发了以下新型铱配合物催化剂。(1)阳离子铱配合物是一种新型高效的刘易斯酸催化剂，可用于Mukaiyama羟醛缩合反应和Mannich反应。(2)中性铱配合物/联芳基双膦是α，ω-二炔与异氰酸酯、腈进行[2+2+2]环加成反应的有效催化剂。

Iridium-catalyzed synthetic reaction hasbeen less developed than cobalt-, rhodium-, ruthenium-and palladium-catalyzed synthetic reaction. During this project, we have developed the following novel catalysis of iridium complex.(1) Cationic iridium complex is a new efficient Lewis acid catalyst for Mukaiyama aldol reaction and Mannich reaction.(2) Neutral iridium complex/biaryldiphosphine is an efficient catalyst for[2+2+2] cycloaddition ofα,ω-diynes with isocyanates and nitrilesto give heterocyclic compounds.