Identification and molecular population genetics analysis of speciation genes in Drosophila

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Previously we succeeded to make an interspecific introgression line in which a part of the genomes of Drosophila melanogaster is replaced by the homologous genes from Drosophila simulans. Introgression homozygotes are sterile both in females and males and the introgression results in recessive lethality when crossed to D. simulans. Thus, the introgression provides an opportunity to genetically analyze reproductive isolation. In the present research, we indicated that Nucleoporin 160 is responsible for the hybrid female sterility and inviability.