Optically active diarylmethanols in the synthesis of pharmacologically interesting lignan derivatives

对对映体纯净化合物的需求不断增加，促使化学家们设计出具有更高效率和环境相容性的催化不对称体系。另一方面，开发更有效的方法来获得对映纯的重要药理化合物是世界范围内最重要的需求之一。目前的项目涉及亚琛工业大学Carsten Bolm教授领导的研究小组和巴黎第六大学Giovanni Poli教授领导的研究小组之间的联合合作。前者在不对称催化方面有着长期的技能，最近将其兴趣集中在构建对构异构富集的二烷基甲醇（苯甲醇）上。另一方面，巴黎团队，其主要专长是致力于钯化学和杂环靶点，目前从事合成药理学和合成有趣的木脂素衍生物。有趣的是，前一个团队获得的富对映二甲醇似乎是后一个团队计划的合成策略的理想前体。由于发现了这样一个共同点，这两个小组决定进行一个联合项目。因此，本项目要求资助一名博士生及其研究相关的消耗性化学品。上述联合项目将促进两个合作研究小组的相互科学丰富，并将进一步帮助新欧洲时代的青年研究人员融合。预计这种合作将利用两组的互补专业知识，以便在开发越来越有效的途径以获得对映纯药理学上有趣的产品方面获得协同效应。

The increasing demand of enantiomerically pure compounds is constantly spurring chemists to design catalytic asymmetric systems endowed of improved efficiency and environmentally compatible. On the other hand, the development of more and more efficient methods to obtain enantiopure pharmacologically important compounds is one of the most important needs world-wide. The present project deals with a joint cooperation between the research team directed by Professor Carsten Bolm at the RWTH Aachen and that directed by Professor Giovanni Poli at the University of Paris VI. The former team, which has a longstanding skill in asymmetric catalysis, has recently focused one of its interests in the construction of enantiomerically enriched diarylmethanols (benzhydrols). On the other hand, the Paris team, whose main expertise is devoted to palladium chemistry and heterocyclic targets, is presently engaged in the synthesis of pharmacologically and synthetically interesting lignan derivatives. Interestingly, the enantionriched diarymethanols obtained by the former team appear to be ideal precursors in the synthetic strategy planned by the latter team. The finding of such a common point led the two groups to settle a joint project. Accordingly, financial support for one PhD student, and the consumable chemicals associated to his research were requested in the present project. The above joint project should promote the mutual scientific enrichment of the two collaborating research groups, and will further help integration of young researchers in the new European era. Such collaboration is expected to exploit the complementary expertise of the two groups so as to gain a synergic effect in the development of more and more efficient routes to enantiopure pharmacologically interesting products.