Optically active diarylmethanols in the synthesis of pharmacologically interesting lignan derivatives

对对映体纯化合物的需求不断增加，不断地促使化学家们设计出效率更高、环境友好的催化不对称体系。另一方面，开发更多更有效的方法来获得对映体具有重要药理作用的化合物是世界上最重要的需求之一。本项目涉及由亚琛理工大学的Carsten Bolm教授和巴黎第六大学的Giovanni Poli教授领导的研究小组的联合合作。前者在不对称催化方面拥有长期的技能，最近将其兴趣集中在构建对映体富含二芳基甲烷醇(苯氢化物)上。另一方面，巴黎团队的主要专长是钯化学和杂环靶标，目前正在致力于合成具有药理和合成兴趣的木脂素衍生物。有趣的是，前者获得的富含对映体的二芳醇似乎是后者计划的合成策略中的理想前体。由于找到了这样一个共同点，两个小组最终达成了一个联合项目。因此，本项目要求为一名博士生提供财政支持，并支付与其研究有关的消耗性化学品。上述联合项目将促进两个合作研究小组在科学上的相互丰富，并将进一步有助于青年研究人员在新欧洲时代的融合。预计这种合作将利用两个小组的互补专业知识，以便在开发更多和更有效的途径以获得具有药理意义的产品方面取得协同效应。

The increasing demand of enantiomerically pure compounds is constantly spurring chemists to design catalytic asymmetric systems endowed of improved efficiency and environmentally compatible. On the other hand, the development of more and more efficient methods to obtain enantiopure pharmacologically important compounds is one of the most important needs world-wide. The present project deals with a joint cooperation between the research team directed by Professor Carsten Bolm at the RWTH Aachen and that directed by Professor Giovanni Poli at the University of Paris VI. The former team, which has a longstanding skill in asymmetric catalysis, has recently focused one of its interests in the construction of enantiomerically enriched diarylmethanols (benzhydrols). On the other hand, the Paris team, whose main expertise is devoted to palladium chemistry and heterocyclic targets, is presently engaged in the synthesis of pharmacologically and synthetically interesting lignan derivatives. Interestingly, the enantionriched diarymethanols obtained by the former team appear to be ideal precursors in the synthetic strategy planned by the latter team. The finding of such a common point led the two groups to settle a joint project. Accordingly, financial support for one PhD student, and the consumable chemicals associated to his research were requested in the present project. The above joint project should promote the mutual scientific enrichment of the two collaborating research groups, and will further help integration of young researchers in the new European era. Such collaboration is expected to exploit the complementary expertise of the two groups so as to gain a synergic effect in the development of more and more efficient routes to enantiopure pharmacologically interesting products.