Optically active diarylmethanols in the synthesis of pharmacologically interesting lignan derivatives

光学活性二芳基甲醇在药理学上有趣的木脂素衍生物合成中的应用

• 批准号: 5380557
• 负责人: Professor Dr. Carsten Bolm
• 金额: --
• 依托单位: Institut Parisien de Chimie Moléculaire (IPCM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5380557?language=en
• 关键词: Optically; active; diarylmethanols; synthesis; pharmacologically

The increasing demand of enantiomerically pure compounds is constantly spurring chemists to design catalytic asymmetric systems endowed of improved efficiency and environmentally compatible. On the other hand, the development of more and more efficient methods to obtain enantiopure pharmacologically important compounds is one of the most important needs world-wide. The present project deals with a joint cooperation between the research team directed by Professor Carsten Bolm at the RWTH Aachen and that directed by Professor Giovanni Poli at the University of Paris VI. The former team, which has a longstanding skill in asymmetric catalysis, has recently focused one of its interests in the construction of enantiomerically enriched diarylmethanols (benzhydrols). On the other hand, the Paris team, whose main expertise is devoted to palladium chemistry and heterocyclic targets, is presently engaged in the synthesis of pharmacologically and synthetically interesting lignan derivatives. Interestingly, the enantionriched diarymethanols obtained by the former team appear to be ideal precursors in the synthetic strategy planned by the latter team. The finding of such a common point led the two groups to settle a joint project. Accordingly, financial support for one PhD student, and the consumable chemicals associated to his research were requested in the present project. The above joint project should promote the mutual scientific enrichment of the two collaborating research groups, and will further help integration of young researchers in the new European era. Such collaboration is expected to exploit the complementary expertise of the two groups so as to gain a synergic effect in the development of more and more efficient routes to enantiopure pharmacologically interesting products.

对映体纯化合物的需求不断增长，不断促使化学家设计出具有更高效率和环境相容性的催化不对称系统。另一方面，开发越来越有效的方法来获得对映体纯的药理学上重要的化合物是全世界最重要的需求之一。本项目涉及亚琛工业大学 Carsten Bolm 教授领导的研究团队与巴黎第六大学 Giovanni Poli 教授领导的研究团队之间的联合合作。前一个团队在不对称催化方面拥有长期的技术，最近将其兴趣之一集中在对映体富集的二芳基甲醇（二苯甲基）的构建上。另一方面，巴黎团队的主要专业知识致力于钯化学和杂环靶标，目前正致力于药理学和合成上有趣的木脂素衍生物的合成。有趣的是，前一个团队获得的富含对映体的二芳基甲醇似乎是后一个团队计划的合成策略中的理想前体。发现这样的共同点促使两个小组达成了一个联合项目。因此，本项目要求为一名博士生以及与其研究相关的消耗性化学品提供财政支持。上述联合项目应能促进两个合作研究小组相互的科学充实，并将进一步有助于新欧洲时代年轻研究人员的融合。这种合作预计将利用两个小组的互补专业知识，以便在开发更多、更有效的对映体纯药理学产品的开发过程中获得协同效应。