Optically active diarylmethanols in the synthesis of pharmacologically interesting lignan derivatives

光学活性二芳基甲醇在药理学上有趣的木脂素衍生物合成中的应用

• 批准号: 5380557
• 负责人: Professor Dr. Carsten Bolm
• 金额: --
• 依托单位: Institut Parisien de Chimie Moléculaire (IPCM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5380557?language=en
• 关键词: Optically; active; diarylmethanols; synthesis; pharmacologically

The increasing demand of enantiomerically pure compounds is constantly spurring chemists to design catalytic asymmetric systems endowed of improved efficiency and environmentally compatible. On the other hand, the development of more and more efficient methods to obtain enantiopure pharmacologically important compounds is one of the most important needs world-wide. The present project deals with a joint cooperation between the research team directed by Professor Carsten Bolm at the RWTH Aachen and that directed by Professor Giovanni Poli at the University of Paris VI. The former team, which has a longstanding skill in asymmetric catalysis, has recently focused one of its interests in the construction of enantiomerically enriched diarylmethanols (benzhydrols). On the other hand, the Paris team, whose main expertise is devoted to palladium chemistry and heterocyclic targets, is presently engaged in the synthesis of pharmacologically and synthetically interesting lignan derivatives. Interestingly, the enantionriched diarymethanols obtained by the former team appear to be ideal precursors in the synthetic strategy planned by the latter team. The finding of such a common point led the two groups to settle a joint project. Accordingly, financial support for one PhD student, and the consumable chemicals associated to his research were requested in the present project. The above joint project should promote the mutual scientific enrichment of the two collaborating research groups, and will further help integration of young researchers in the new European era. Such collaboration is expected to exploit the complementary expertise of the two groups so as to gain a synergic effect in the development of more and more efficient routes to enantiopure pharmacologically interesting products.

对映体纯化合物的需求不断增长，不断刺激化学家设计催化不对称系统，这些系统具有提高效率和环境兼容的催化不对称系统。另一方面，开发越来越有效的方法以获取对对映体具有重要意义的化合物是全球最重要的需求之一。本项目介绍了卡斯滕·博尔姆（Carsten Bolm）教授在亚兴（Rwth Aachen）执导的研究团队与巴黎大学六世大学乔瓦尼·波利（Giovanni Poli）指导的研究团队之间的合作。这位前团队在不对称催化方面具有长期技能，最近将其兴趣之一集中在建造映体富集的二丁二醇（苯并二醇）上。另一方面，巴黎团队的主要专业知识致力于钯化学和杂环靶标，目前正从事药理和合成有趣的木质衍生物的合成。有趣的是，前团队获得的对映射日记甲醇似乎是后者团队计划的合成策略中的理想先驱。这种共同点的发现导致两个小组解决联合项目。因此，在本项目中要求对一名博士学位学生以及与他的研究相关的消耗性化学物质的财政支持。上述联合项目应促进两个合作研究小组的相互科学丰富，并将进一步帮助在新欧洲时代的年轻研究人员整合。预计这种合作将利用这两组的互补专业知识，从而在开发更有效的途径来对映射药理学有趣的产品的开发中产生协同效应。