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Roles of AAA peroxins in peroxisome biogenesis

Roles of AAA peroxins in peroxisome biogenesis
AAA 过氧化物酶在过氧化物酶体生物发生中的作用
批准号:
21570116
负责人:
TAMURA Shigehiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The aim of this study is to investigate the molecular mechanism of peroxisome biogenesis. Pexl4p is a central component of the peroxisomal protein import machinery, in which the conserved Nterminal domain mediates dynamic interactions with Pex5p. We reported the crystal structure of the conserved Nterminal domain of Pexl4p with a three-helix bundle. Furthermore, AAA peroxins are most likely regulated in their peroxisomal localization onto Pex26p via conformational changes by the ATPase cycle, and modulatethe interaction between Pex26p and Pexl4p on peroxisome membrane.
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Monomer-dimer transition of the conserved N-terminal domain of the mammalian peroxisomal matorix protein import receptor, Pex14p
哺乳动物过氧化物酶体 matorix 蛋白输入受体 Pex14p 保守 N 端结构域的单体-二聚体转变
DOI: --
发表时间: 2010
期刊: Biochem.Biophys.Res.Commun. 394
影响因子: --
作者: [Su, J.R, et.al.]
通讯作者: et.al.
Recruiting mechanism of the AAA peroxins
AAA过氧化物酶的招募机制
DOI: --
发表时间: 2011
期刊: Pexlp and Pex6p, to Pex26p on the peroxisomal membrane. Traffic
影响因子: --
作者: [Nashiro, C., Kashiwag, A., Matsuzaki, T., Tamura, S. and Fujiki, Y.]
通讯作者: Y.
Crystal structure of the conserved N-terminal domain of the peroxisomal matrix protein import receptor, Pexl4p
过氧化物酶体基质蛋白输入受体 Pexl4p 保守 N 端结构域的晶体结构
DOI: --
发表时间: 2009
期刊: Proceedings of the National Academy of Sciences 106
影响因子: --
作者: [Su, J.-R., et.al.]
通讯作者: et.al.
Recruiting Mechanism of the AAA peroxins, Pex1p and Pex6p, to Pex26p on peroxisome Membrane
AAA 过氧化物酶、Pex1p 和 Pex6p 在过氧化物酶体膜上向 Pex26p 的募​​集机制
DOI: --
发表时间: 2011
期刊: Traffic
影响因子: 4.5
作者: [Nashiro, C., et al]
通讯作者: et al
15
    Identification of core components of peroxisomal membrane translocator
    • 批准号:
      24570134
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.58万
    • 财政年份:
      2012
    • 负责人:
      TAMURA Shigehiko
    • 依托单位:
    A new approach for the AAA peroxin research
    • 批准号:
      18570111
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.59万
    • 财政年份:
      2006
    • 负责人:
      TAMURA Shigehiko
    • 依托单位:
    Identification of novel pathogenic gene and genotype phenotype correlation in peroxisome biogenesis disorders
    • 批准号:
      15570100
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2003
    • 负责人:
      TAMURA Shigehiko
    • 依托单位:
    Identification of novel PEX gene and functional analysis of Pexlp in peroxisome biogenesis
    • 批准号:
      13680694
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2001
    • 负责人:
      TAMURA Shigehiko
    • 依托单位:
    海外基金