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Exploration of factors that have an influence on reassortment of influenza A virus

Exploration of factors that have an influence on reassortment of influenza A virus
影响甲型流感病毒重排的因素探讨
批准号:
21580372
负责人:
GOTO Hideo
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

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中文摘要
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英文摘要
To explore causes that have an influence on reassortment of influenza A virus, virus like particles that carried HA and NA genome segments expressing split reporter proteins were generated. Reporter activity by protein complementation was detectable in cells transfected with protein expression plasmids. However the activity was reduced to 1/105 of the wild type activity. Due to the significant reduction of the activity the complementation could not be detected upon the VLP infection. The different amount of protein production between HA and NA segments may contribute the undetectable complementation upon VLP infection
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DOI: 10.1016/j.jviromet.2010.12.014
发表时间: 2011-04
期刊: JOURNAL OF VIROLOGICAL METHODS
影响因子: 3.1
作者: [Kawakami, Eiryo, Watanabe, Tokiko, Fujii, Ken, Goto, Hideo, Watanabe, Shinji, Noda, Takeshi, Kawaoka, Yoshihiro]
通讯作者: Kawaoka, Yoshihiro
Sumoylation of influenza A virus nonstructural protein 1 is important for type I interferon antagonism and pathogenicity
甲型流感病毒非结构蛋白 1 的苏酰化对于 I 型干扰素拮抗和致病性很重要
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kakugawa S, Shimojima M, Neumann G, Goto H, Kawaoka Y, Ozawa M, Konno H, T. Gorai]
通讯作者: T. Gorai
DOI: 10.1371/journal.pone.0005674
发表时间: 2009-05-25
期刊: PloS one
影响因子: 3.7
作者: [Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J]
通讯作者: Inoue J
DOI: 10.1038/nature09420
发表时间: 2010-10-14
期刊: NATURE
影响因子: 64.8
作者: [Arii, Jun, Goto, Hideo, Kawaguchi, Yasushi]
通讯作者: Kawaguchi, Yasushi
13
    Study on a role of receptor destruction in homologous viral interference by Sendai virus using persistently infected cells.
    Study on development of a live attenuated vaccine for equine influenza infection using reverse genetics
    • 批准号:
      13556052
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.96万
    • 财政年份:
      2001
    • 负责人:
      GOTO Hideo
    • 依托单位:
    An morphological study of qubernacular foramen (macroscopically, light microscopically and electron microscopically observation)
    • 批准号:
      05671722
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1993
    • 负责人:
      GOTO Hideo
    • 依托单位:
    The morphogical and histrogical study of the foramen gubernacular
    • 批准号:
      62570924
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $0.96万
    • 财政年份:
      1987
    • 负责人:
      GOTO Hideo
    • 依托单位:
    海外基金