Development of nucleophilic cyanation to non-activated alkynes

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Nucleophilic cyanation has been developed by using catalytic amount of Pd(II) with non-activated alkynes and CN source. This fundamental and non-reported transformation in organometallic chemistry is named as cyanopalladation which promote electrophilic activation of alkynes and smooth nucleophilic attack from external CN source such as TMSCN. Furthermore, enynes and dienynes which have conjugated enyne units have been found for quite suitable substrates to install CN functionality in regio- and stereoselective fashion through cyclization protocol.