Construction of CD-Sensitive Porphyrin Tweezer Systems and Their Application for the Direct Sensing of Chiral Organic Molecules

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Design, synthesis, and chirogenetic properties of novel pseudo-cofacial zinc porphyrin tweezers as an efficient circular dichroism(CD)-sensitive host molecule were explored. The notable features of the new tweezer systems are their facile synthetic accessibility and high binding affinity for a variety of optically active molecules, including diols, alcohols, and epoxides as well as amines, diamines, and aminoalcohols, providing an efficient direct, non-empirical determination of absolute configuration of these substrates at room temperature without the need for chemical derivatization.