Hyperreactivity of thermo-sensitive TRP channel-expressing sensory neurons under stress conditions, and effects of herbal medicines on hyperesthesia

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Psychological stress induces impairment of gastrointestinal tracts, leading to irritable bowel syndrome(IBS) accompanied by abdominal pain. The present study was designed with IBS model animals in order to elucidate the causes of IBS. As an important result, the stress induces the increased number of thermosensitive TRPV1-expressing nerve fibers, resulting in the hypersensitivity of visceral pain. Therefore, the inhibition of the abnormality of TRPV1 nerves in gut will make a contribution to the treatment of irritable bowel syndrome. I propose that Japanese Kampo medicine such as Daikenchuto will be a candidate that has the inhibitory effect of the abnormality on TRPV1 nerves in gut.