Funtional significances of the diversity of the delta-protocadherins in the neuro-and organ-developments

本研究以斑马鱼为实验动物模型，探讨δ-原钙粘蛋白（Pcdh’s）的多样性在中枢神经系统和各种器官发育中的功能意义。pcdh 9开始在前脑、腹侧后脑和脊髓的一些细胞中表达。其在脑中的表达随着发育而增加，而在脊髓中的表达则减少。Pcdh 17和Pcdh 9的表达模式相似，但在细节模式上有明显差异。Pcdh 19的表达开始于神经龙骨，并扩展到大脑，眼睛和耳囊。pcdh 10 a在透镜、耳囊和脑的某些部位特异性表达。敲低Pcdh 10a导致眼结构畸形，但其渗透性相对较低，这表明未知的互补粘附分子。

This project was to elucidate the functional significance of the diversity of the delpta-protocadherins (Pcdh's) in the development of the CNS and various organs using zebrafish as an experimental model. Pcdh9 started to express in some cells of the forebrain, the ventral hindbrain, and the spinal cord. Its expression in the brain increased over development, while that in the spinal cord decreased. The expression pattern of Pcdh17 was similar to that of Pcdh9, though had distinct differences in detailed patterns. The expression of Pcdh19 started in the neural keel, and expanded to the brain, the eyes, and the otocysts. Pcdh10a specifically expressed in the lens, the otocysts, and certain parts of the brain. Knock-down of Pcdh10a caused deformities of eye structures, though its penetration was relatively low, suggesting unknown complementary adhesion molecules.