Receptor tyrosine kinase-mediated development and differentiation of interstitial cells in the gastrointestinal tract

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We observed the expression of receptor tyrosine kinase, c-Kit and PDGFRα, that are specific markers of interstitial cells of Cajal and fibroblast-like cells in the murine gastrointestinal tract. c-Kit expression was observed in gastrointestinal tract from mid embryonic stage. W mutant mice that have c-kit mutations showed cell type specific deficiency of interstitial cells of Cajal. PDGFRαexpression in gastrointestinal tract was observed from early embryonic stage in mesoderm cells and in fibroblast-like cells in late embryonic stage.