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Mechanism by which fatty acid binding proteins regulate the cellular signal transduction

Mechanism by which fatty acid binding proteins regulate the cellular signal transduction
脂肪酸结合蛋白调节细胞信号转导的机制
批准号:
21590215
负责人:
OWADA Yuji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
In this study, we examined the role of fatty acid binding proteins in the regulation of cellular signal transduction, mainly by using FABP-deficient mice. The following results have been so far obtained :(1) epidermal-type FABP(FABP5) is involved in the early differentiation process of mouse keratinocytes though the regulation of linoleic acid metabolism(Ogawa et al., J Invest Dermatol, 2011).(2) brain-type FABP(FABP7) is involed in the proliferation of astrocytes through the regulation of omega-3 polyunsaturated fatty acid metabolism(Sharifi et al., Histochem Cell Biol, 2011).
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会议论文
Expression of FABP7 in normal and injured brain cortex and its role in astrocyte proliferation
FABP7在正常和损伤大脑皮层中的表达及其在星形胶质细胞增殖中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kazem Sharifi, ら]
通讯作者:
脂肪酸結合タンパク質(FABP7)のクッパー細胞における発現とその意義
脂肪酸结合蛋白(FABP7)在Kupffer细胞中的表达及其意义
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [澤田知夫, 中村啓二, 中原有海, 清平美和, 徳田信子, 安達泰弘, 大和田祐二]
通讯作者: 大和田祐二
Epidermal FABP (FABP5) regulates keratinocyte differentiation via 13(S)-HODE mediated activation of the NF-kB signaling pathway.
表皮 FABP (FABP5) 通过 13(S)-HODE 介导的 NF-kB 信号通路激活调节角质形成细胞分化。
DOI: --
发表时间: 2011
期刊: J Invest Dermatol 131
影响因子: --
作者: [Ogawa, E., Owada Y., Ikawa, S., Adachi, Y., Egawa, T., Nemoto, K., Suzuki, K., Hishinuma, T., Kawashima, H., Kondo, H., Muto, M., Aiba, S., Okuyama, R.]
通讯作者: R.
心臓型脂肪酸結合タンパク質による中枢ドパミン神経活動の調節
心型脂肪酸结合蛋白对中枢多巴胺神经元活性的调节
DOI: --
发表时间: 2011
期刊: 薬学雑誌 131
影响因子: --
作者: [山本由似, 塩田倫史, 大和田祐二, 福永浩司]
通讯作者: 福永浩司
37
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