On the role of amygdala in emotional response during REM sleep

杏仁核在快速眼动睡眠期间情绪反应中的作用

• 批准号: 21590250
• 负责人: KOYAMA Yoshimasa
• 金额: $ 3万
• 依托单位: Fukushima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590250/
• 关键词: 脳・神経; レム睡眠; 自律神経系; 情動; 夢; 扁桃体; 徐波睡眠; ラット

More than half of the neurons in the amygdala showed higher activity during REM sleep than during other stages (wakefulness and slow wave sleep). These neurons did not fire continuously through REM sleep, but showed phasic or burstic firing at some restricted period of REM sleep. Some of the amygdala neurons displayed firing in synchronous with large fluctuations of blood pressure. These results suggest that the amygdala have crucial roles in the changes of autonomic nervous system occurring during REM sleep, which would be closely related with emotional changes during REM sleep.

杏仁核中超过一半的神经元在REM睡眠期间比其他阶段（清醒和慢波睡眠）表现出更高的活性。这些神经元在REM睡眠中并不持续放电，而是在REM睡眠的某个限定时期表现出阶段性或爆发性放电。一些杏仁核神经元的放电与血压的大幅波动同步。这些结果提示杏仁核在快速眼动睡眠期自主神经系统的变化中起着重要的作用，而自主神经系统的变化与快速眼动睡眠期的情绪变化密切相关。

项目成果

オレキシン神経欠損マウスにおけるモノアミン神経活動の変化

食欲素神经缺陷小鼠单胺神经元活性的变化

• 发表时间: 2009
• 作者: 辻野なつ子;常松友美;山中章弘;小山純正;櫻井武
• 通讯作者: 櫻井武

GABA release from the sunstantia nigra pars reticulata and the pedunculopontine tegmental nucleus is facilitated by orexin

食欲素促进黑质网状部和脚桥被盖核释放 GABA

• 发表时间: 2009
• 作者: Koyama Y;Takahashi K;Honda H;Kodama T.
• 通讯作者: Kodama T.

扁桃体ニューロンにより睡眠中に生じる大きな血圧変動

睡眠期间杏仁核神经元引起的血压大幅波动

• 发表时间: 2012
• 作者: Ibhazehiebo K;Iwasaki T;Kimura-Kurods J;Miyazaki W;Shimokawa N;Koibuchi N.;外舘圭一,松田翔平,青柳俊史,豊巻知史,辛島彰洋,小山純正
• 通讯作者: 外舘圭一,松田翔平,青柳俊史,豊巻知史,辛島彰洋,小山純正

Orexin facilitates GABA release from the sunstantia nigra pars reticulata and the pedunculopontine tegmental nucleus that regulate muscular tonus

食欲素促进黑质网状部和脚桥被盖核释放 GABA，调节肌肉紧张

• 发表时间: 2009
• 作者: K.Takahashi;T.Kodama;Y.Honda;Y.Koyama
• 通讯作者: Y.Koyama

Acupuncture of the sacral segment suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center

针刺骶段抑制脑干排尿中枢膀胱活动及膀胱活动相关神经元

• 发表时间: 2012
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Wang H;Tanaka H;Kawauchi A;Miki T;Kayama Y and Koyama Y
• 通讯作者: Kayama Y and Koyama Y