Suppressive role of histamine in inflammation-associated tumorigenesis
Suppressive role of histamine in inflammation-associated tumorigenesis
批准号:
21590268
负责人:
KURAMASU Atsuo
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Role of histamine in inflammation-associated tumorigenesis was investigated using mice deficient of endogenous histamine. In colitis-associated colon cancer model, mice lacking histamine had significantly larger tumors, suggesting that histamine has suppressive role in tumor growth. In spleen from histamine-deficient mice with colon tumor, myeloid-derived suppressor cells(MDSCs) were increased, showing a possible mechanism of MDSC-mediated suppression of anti-tumor immune response.
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DOI:
10.1016/j.cellsig.2011.06.021
发表时间:
2011-11
期刊:
Cellular signalling
影响因子:
4.8
作者:
[Atsuo Kuramasu;J. Sukegawa;Takeya Sato;E. Sakurai;Takehiko Watanabe;T. Yanagisawa;K. Yanai]
通讯作者:
Atsuo Kuramasu;J. Sukegawa;Takeya Sato;E. Sakurai;Takehiko Watanabe;T. Yanagisawa;K. Yanai
Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward : a study of receptors gene knockout mice
组胺能神经传递对甲基苯丙胺诱导的运动敏化和奖赏的作用:受体基因敲除小鼠的研究
DOI:
--
发表时间:
2009
期刊:
Int Rev Neurobiol
影响因子:
--
作者:
[Takino N, Sakurai E, Kuramasu A, Okamura N, Yanai K]
通讯作者:
Yanai K
DOI:
10.1254/jphs.10177fp
发表时间:
2010
期刊:
Journal of pharmacological sciences
影响因子:
3.5
作者:
[A. Xu;E. Sakurai;Atsuo Kuramasu;Jian Zhang;Jiyu Li;N. Okamura;Dongying Zhang;T. Yoshikawa;Takehiko Watanabe;K. Yanai]
通讯作者:
A. Xu;E. Sakurai;Atsuo Kuramasu;Jian Zhang;Jiyu Li;N. Okamura;Dongying Zhang;T. Yoshikawa;Takehiko Watanabe;K. Yanai
ヒスタミンH3受容体のヘリックス8はGタンパク質との共役に重要である
组胺 H3 受体的螺旋 8 对于与 G 蛋白的偶联非常重要
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[倉増敦朗, 助川淳, 櫻井映子, 渡邉建彦, 柳澤輝行, 谷内一彦]
通讯作者:
谷内一彦
Multiple histamine receptor gene knockout mice and their phenotypes.
多组胺受体基因敲除小鼠及其表型。
DOI:
--
发表时间:
2009
期刊:
Inflammation Research 58
影响因子:
--
作者:
[Sakurai E, Kuramasu A, Watanabe T, Yanai K.]
通讯作者:
Yanai K.
共 7 条
Elucidation of the molecular mechanism and functional significance of histaminylation, a novel post-translational modification
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批准号:19K07320
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
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负责人:KURAMASU Atsuo
-
依托单位:
Suppressive role of histamine in hepatic colorectal cancer matastasis
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批准号:24590322
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
-
财政年份:2012
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负责人:KURAMASU Atsuo
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依托单位:
海外基金