Analysis of expression mechanisms of neuroendocrine cancer cell-specific molecules via TTF-1

TTF-1分析神经内分泌癌细胞特异性分子的表达机制

• 批准号: 21590376
• 负责人: YAZAWA Takuya
• 金额: $ 3万
• 依托单位: Kyorin University (2011)Yokohama City University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590376/
• 关键词: 肺がん; 悪性神経内分泌細胞; TTF-1; 肺癌; 悪性神経内分泌腫瘍

Thyroid transcription factor-1(TTF-1) is frequently expressed in lung adenocarcinomas with peripheral airway epithelium-like phenotype. However, frequent and abundant TTF-1 expression is also paradoxically found in small cell lung cancers, which commonly generate from central airway. The aim of this study was to investigate the expression mechanism of TTF-1 and search downstream molecules regulated by TTF-1.Through this study, it was suggested that TTF-1 expression was not epigenetically regulated and that TTF-1 complicatedly regulated gene expression with other homeobox transcription factors and neuroendocrine-specific basic helix-loop-helix transcription factors cooperatively.

甲状腺转录因子-1（TTF-1）常在具有外周气道上皮样表型的肺腺癌中表达。然而，TTF-1的频繁和丰富的表达也被矛盾地发现在小细胞肺癌，这通常产生于中央气道。本研究的目的是探讨TTF-1的表达机制，寻找TTF-1调控的下游分子。研究结果表明，TTF-1的表达不受表观遗传学调控，而是与其他同源框转录因子和神经内分泌特异性碱性螺旋-环-螺旋转录因子协同复杂地调控基因表达。

项目成果

Pneumothorax and idiopathic pulmonary fibrosis

• DOI: 10.1007/s11604-010-0494-1
• 发表时间: 2010-11-01
• 期刊: JAPANESE JOURNAL OF RADIOLOGY
• 影响因子: 2.1
• 作者: Iwasawa, Tae;Ogura, Takashi;Inoue, Tomio
• 通讯作者: Inoue, Tomio

Small Cell Lung Cancer: Significance of RB Alterations and TTF-1 Expression in its Carcinogenesis, Phenotype, and Biology

• DOI: 10.1007/s12022-009-9072-4
• 发表时间: 2009-06-01
• 期刊: ENDOCRINE PATHOLOGY
• 影响因子: 4.4
• 作者: Kitamura, Hitoshi;Yazawa, Takuya;Shimoyamada, Hiroaki
• 通讯作者: Shimoyamada, Hiroaki

Significant association between EGFR-mutated lung adenocarcinoma and past illness from gastric cancer or uterine myoma: Its implication in carcinogenesis

• DOI: 10.1016/j.lungcan.2009.02.025
• 发表时间: 2009-12-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Okudela, Koji;Woo, Tetsukan;Kitamura, Hitoshi
• 通讯作者: Kitamura, Hitoshi

内分泌腫瘍の病理

内分泌肿瘤病理学

• 发表时间: 2012
• 期刊: 日本内分泌・甲状腺外科学会雑誌
• 作者: 菅間博;矢澤卓也
• 通讯作者: 矢澤卓也

Down-Regulation of DUSP6 Expression in Lung Cancer Its Mechanism and Potential Role in Carcinogenesis

• DOI: 10.2353/ajpath.2009.080489
• 发表时间: 2009-08-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Okudela, Koji;Yazawa, Takuya;Kitamura, Hitoshi
• 通讯作者: Kitamura, Hitoshi