Genetic alteration in the short telomere lesion as a precancerous lesion of gastric cancer

短端粒病变作为胃癌癌前病变的遗传改变

• 批准号: 21590380
• 负责人: FUJII Kiyomu
• 金额: $ 3万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590380/
• 关键词: テロメア; 胃癌; 幹細胞因子; ステムネス; 前癌病変; ヘリコバクター・ピロリ; 幹細胞; 系譜細胞; 分化; テロメラーゼ; クリプト; クリプト関連遺伝子; チトクロムP450; ノーダル; ES細胞

Telomere is shortened in gastric cancer. A semi-quantitative and geographic analysis of telomere in non-cancerous gastric mucosa showed the localized mucosal area with shortened telomere, which was named as short telomere lesion(STL)". In this project, specific genetic alterations in STL were examined. TDGF-2, which is one of pseudogene of CR-1, was deleted in high frequency in STL. TDGF-2 gene product inhibited the physical association of CR-1 and Nodal. The lack of TDGF-2 as a CR-1 negative regulator induced activation of CR-1-Nodal pathway, which might provoke stem cell hyperplasia in gastric epithelium. A variant type of CTP2D6 was expressed in STL, which might affect the metabolism of genotoxic substances.

胃癌中端粒缩短。对非癌性胃粘膜端粒的半定量和地理分析显示，局部粘膜区域端粒缩短，被命名为短端粒病变（STL）。本项目对STL中的特异性基因改变进行了检查。TDGF-2是CR-1的假基因之一，在STL中被高频率删除。TDGF-2基因产物抑制了物理 CR-1 和 Nodal 的关联。缺乏作为 CR-1 负调节因子的 TDGF-2 会诱导 CR-1-Nodal 通路的激活，这可能会引起胃上皮干细胞增生。 STL中表达了CTP2D6的变异型，可能影响基因毒性物质的代谢。

项目成果

Angiotensin in colorectal cancer metastasis

血管紧张素在结直肠癌转移中的作用

• 发表时间: 2012
• 作者: Luo Y;Ohmori H (他8名)
• 通讯作者: Ohmori H (他8名)

HMGB1 Attenuates Anti-Metastatic Defense of the Lymph Nodes in Colorectal Cancer

• DOI: 10.1159/000272950
• 发表时间: 2010-01-01
• 期刊: PATHOBIOLOGY
• 影响因子: 5
• 作者: Moriwaka, Yukiko;Luo, Yi;Kuniyasu, Hiroki
• 通讯作者: Kuniyasu, Hiroki

Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and the metastasis through the expression of high mobility group box 1

膳食亚油酸和葡萄糖通过高迁移率族蛋白1的表达增强氧化偶氮甲烷诱导的结肠癌和转移

• 发表时间: 2010
• 期刊: Pathobiology
• 影响因子: 5
• 作者: Ohmori H;Kuniyasu H;et al
• 通讯作者: et al

HMGB1 affects plasma amino acid profiles in colon carcinogenesis

HMGB1 影响结肠癌发生过程中的血浆氨基酸谱

• 发表时间: 2011
• 作者: Luo Y;Yoneda J;Ohmori H;Shimbo K;Eto S;Fujii K;Sasahira T;Chihara Y;Kuniyasu H
• 通讯作者: Kuniyasu H

Expression of MAS1 in breast cancer.

• DOI: 10.1111/cas.12719
• 发表时间: 2015-09
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Luo Y;Tanabe E;Kitayoshi M;Nishiguchi Y;Fujiwara R;Matsushima S;Sasaki T;Sasahira T;Chihara Y;Nakae D;Fujii K;Ohmori H;Kuniyasu H
• 通讯作者: Kuniyasu H