Short telomere lesion as a.precancerous condition of gastric cancer

局部短端粒病变作为胃癌癌前病变检查。(1)胃癌中端粒体积减少至浸润淋巴细胞的10440%。(2)在胃癌附近粘膜，靠近癌灶的粘膜端粒体积小于远离癌灶的粘膜端粒体积。(3)非癌性粘膜的Palomar体积为化生性粘膜的70-90%，淋巴细胞非化生性粘膜的70-90%。(4)幽门螺杆菌诱导的活动性胃炎粘膜端粒体积明显小于活动性低的粘膜。(5)全胃切片检查在远离癌的胃黏膜中发现端粒缩短的局部粘膜区。在这些区域，端粒体积比邻近粘膜低15-35%。这些区域被称为“短端粒病变”，没有特征性的内镜和组织学发现，病变被观察为通常的萎缩性胃炎伴化生或非化生粘膜，轻度异型。(6)短端粒病变出现干细胞增生，且分布无组织。(7)在短端粒病变中，该基因的缺失，这是之前由共同研究者报道的。这些特征提示短端粒病变作为胃癌的癌前病变或状态是重要的。

Localized short telomere lesion was examined as a precancerous lesion of gastric cancer. (1) In gastric cancer, telomere volumes were reduced to 10440% of those in the infiltrating lymphocytes. (2) In the mucosa vicinity of gastric cancer, the mucosa nearer to cancer lesions showed less telomere volumes than those in the mucosa distant from cancer. (3) 'Palomar volumes in the non cancerous mucosa were 70-90% in the metaplastic mucosa and 70-90% in the non-metasplastic mucosa of those in the lymphocytes. (4) The mucosa with IL pylori-induces active gastritis showed more reduced telomere volumes than the mucosa with low activity. (5) The localized mucosal areas with shortened telomeres were detected in gastric mucosa distant from cancer by whole gastric sections examination. In these areas, telomere volumes were lower by 15-35% of the neighboring mucosas. These areas, called by "short telomere lesions", showed no characteristic endoscopical nor histological findings, The lesions were observed as usual atrophic gastritis with metaplasia or non-metaplastic mucosa with mild atypia. (6) In the short telomere lesions, stem cell hyperplasia with disorganized distribution was found. (7) In the short telomere lesions, deletion of the gene, which was previously reported by the co-investigator. These features are suggesting that the short telomere lesion is important as a precancerous lesion or condition of gastric cancer.