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Short telomere lesion as a.precancerous condition of gastric cancer

端粒短损伤是胃癌的癌前病变

基本信息

批准号：
18590340
负责人：
FUJII Kiyomu
金额：
$ 1.93万
依托单位：
Nara Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590340/
关键词：
Telomere Stem cell Gastric cancer Precancerous lesion Gene deletion Intestinal metaplasia 腸上皮化 H.pylori 前がん病変

项目摘要

Localized short telomere lesion was examined as a precancerous lesion of gastric cancer. (1) In gastric cancer, telomere volumes were reduced to 10440% of those in the infiltrating lymphocytes. (2) In the mucosa vicinity of gastric cancer, the mucosa nearer to cancer lesions showed less telomere volumes than those in the mucosa distant from cancer. (3) 'Palomar volumes in the non cancerous mucosa were 70-90% in the metaplastic mucosa and 70-90% in the non-metasplastic mucosa of those in the lymphocytes. (4) The mucosa with IL pylori-induces active gastritis showed more reduced telomere volumes than the mucosa with low activity. (5) The localized mucosal areas with shortened telomeres were detected in gastric mucosa distant from cancer by whole gastric sections examination. In these areas, telomere volumes were lower by 15-35% of the neighboring mucosas. These areas, called by "short telomere lesions", showed no characteristic endoscopical nor histological findings, The lesions were observed as usual atrophic gastritis with metaplasia or non-metaplastic mucosa with mild atypia. (6) In the short telomere lesions, stem cell hyperplasia with disorganized distribution was found. (7) In the short telomere lesions, deletion of the gene, which was previously reported by the co-investigator. These features are suggesting that the short telomere lesion is important as a precancerous lesion or condition of gastric cancer.

局限性短端粒病变是胃癌的癌前病变。(1)在胃癌中，端粒体积减少到浸润淋巴细胞的10440%。(2)在胃癌附近的粘膜中，离癌灶较近的粘膜端粒体积小于远离癌灶的粘膜。(3)非癌粘膜的Palomar体积为化生粘膜的70-90%，非化生粘膜的70-90%。(4)IL pylori诱导的活动性胃炎的粘膜比低活动性的粘膜表现出更多的端粒体积减少。(5)全胃切片检查发现癌旁胃粘膜中存在端粒缩短的局限性粘膜区域。在这些区域中，端粒体积比邻近粘膜低15-35%。这些区域被称为“短端粒病变”，没有显示出特征性的内镜或组织学发现，病变被观察到为通常的萎缩性胃炎伴化生或非化生性粘膜伴轻度胃炎。(6)在短端粒病变中，发现干细胞增生，分布紊乱。（7）在短端粒病变中，基因缺失，这是合作研究者先前报道的。这些特征提示短端粒病变作为胃癌的癌前病变或状况是重要的。