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Analyses for malignant degree of carcinomas based on epithelial-mesenchymal transition, histological characteristics and biological characteristics of carcinoma cells.

基于上皮间质转化、癌细胞的组织学特征和生物学特性分析癌症的恶性程度。

基本信息

批准号：
21590393
负责人：
HASEBE Takahiro
金额：
$ 3万
依托单位：
National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

p53 protein expression in tumor-stromal fibroblasts was closely associated with the number of nodal metastasis and the outcome of invasive ductal carcinoma(IDC) patients of the breast who received and who did not receive neoadjuvant therapy. Furthermore, the Allred score risk classification based on the combined assessment of p53 expression in tumor-stromal fibroblasts forming and not forming FFs is a very useful outcome predictor among patients with IDC who did not receive neoadjuvant therapy.The grading system for lymph vessel tumor emboli was an excellent histological outcome predictive grading system for IDC patients who received and who did not receive neoadjuvant therapy.The presence of atypical tumor-stromal fibroblasts, especially in fibrotic foci, was significantly associated with tumor recurrence and tumor-related death of patients with IDC of the breast who received and who did not receive neoadjuvant therapy.The presence of six or more mitotic figures in a lymph node tumor … More significantly increased the hazard ratios for tumor recurrence and tumor-related death among IDC patients as a whole, those with nodal metastases, and those with a histologic grade of 2 or 3.Type 4 IDC was significant outcome predictors for lymph node-negative and-positive, UICC pTNM stages II and III, luminal A-subtype, luminal B-subtype, and equivocal HER2 subtype IDC patients. Lymph vessel tumor embolus grades 2 and 3 were significant outcome predictors for lymph node-positive, UICC pTNM stages II and III, luminal A-subtype and triple negative IDC patients. A more than five mitotic figures in metastatic carcinoma to the lymph nodes was a significant outcome predictor for lymph node-positive, UICC pTNM stage II and luminal A-subtype IDC patients. A fibrotic focus diameter> 8 mm was a significant outcome predictor for UICC pTNM stages I and III IDC patients.The modified PVN classification clearly exhibited a superior significant power, compared with UICC pTNM classification and the reclassified Nottingham Prognostic Index, for the accurate prediction of tumor recurrence and tumor-related death among patients with IDC in a manner that was independent of the nodal status, the hormone receptor status and adjuvant therapy status. Less

肿瘤间质成纤维细胞中p53蛋白表达与接受和未接受新辅助治疗的乳腺浸润性导管癌（IDC）患者的淋巴结转移数量和预后密切相关。此外，委员会认为，基于肿瘤中p53表达的联合评估的Allred评分风险分类-在未接受新辅助治疗的IDC患者中，基质成纤维细胞形成和不形成FF是一个非常有用的预后预测因子。淋巴管肿瘤栓塞的分级系统是接受和未接受新辅助治疗的IDC患者的一个极好的组织学预后预测分级系统。非典型肿瘤间质成纤维细胞，特别是在纤维化灶中，与接受和未接受新辅助治疗的乳腺IDC患者的肿瘤复发和肿瘤相关死亡显著相关。 ...更多信息 4型IDC是淋巴结阴性和阳性、UICC pTNM II期和III期、管腔A亚型、管腔B亚型和可疑HER 2亚型IDC患者的显著预后预测因子。对于淋巴结阳性、UICC pTNM II期和III期、管腔A亚型和三阴性IDC患者，2级和3级淋巴管肿瘤栓子是显著的预后预测因子。对于淋巴结阳性、UICC pTNM II期和管腔A亚型IDC患者，淋巴结转移癌中超过5个核分裂像是一个重要的预后预测因子。纤维化病灶直径> 8 mm是UICC pTNM I期和III期IDC患者的重要预后预测因子。与UICC pTNM分类和重新分类的诺丁汉预后指数相比，改良PVN分类在准确预测IDC患者肿瘤复发和肿瘤相关死亡方面明显表现出上级显著功效，其方式与淋巴结状态无关，激素受体状态和辅助治疗状态。少

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

リンパ管腫瘍塞栓組織異型度。術前薬物療法浸潤性乳管癌患者の重要な予後因子

淋巴肿瘤栓塞组织异型性。

DOI：
发表时间：
2010
期刊：
影响因子：
0
作者：
長谷部孝裕;他
通讯作者：
他

p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy

DOI：
10.1016/j.humpath.2009.07.021
发表时间：
2010-02-01
期刊：
HUMAN PATHOLOGY
影响因子：
3.3
作者：
Hasebe, Takahiro;Tamura, Nobuko;Kinoshita, Takayuki
通讯作者：
Kinoshita, Takayuki

Tumor histology in lymph vessel and lymph nodes for the accurate prediction of outcome among breast cancer patients treated with neoadjuvant chemotherapy

淋巴管和淋巴结的肿瘤组织学可准确预测接受新辅助化疗的乳腺癌患者的结果

DOI：
10.1111/j.1349-7006.2009.01264.x
发表时间：
2009
期刊：
Cancer Sci
影响因子：
5.7
作者：
T amura N;Hasebe T;Okada N;Houjoh T;Akashi-Tanaka S;Shimizu C;Shibata T;Sasajima Y;Iwasaki M;Kinoshita T
通讯作者：
Kinoshita T

リンパ管腫瘍塞栓組織異型度。乳癌予後因子としての重要性

淋巴肿瘤栓塞组织异型性。