Analyses for the biological characteristics of tumor-stromal fibroblasts and endothelial cells that determine the ability of metastasis and invasion of breast and colorectal cancers.

分析决定乳腺癌和结直肠癌转移和侵袭能力的肿瘤基质成纤维细胞和内皮细胞的生物学特性。

• 批准号: 13670201
• 负责人: HASEBE Takahiro
• 金额: $ 2.18万
• 依托单位: National Cancer Center Research Institute East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670201/
• 关键词: Breast cancer; Invasive ductal carcinoma; Colorectal cancer; Fibroblast; Endothelial cell; Fibrotic focus; Metastasis; Invasion

Prognostic significance of proliferative activity of fibroblasts consisting of a fibrotic focus (FF) in invasive ductal carcinomas (IDCs) of the breast was confirmed by the retrospective analysis. In addition, we prospectively investigated the prognostic significance of a FF in 439 IDC patients, and, clearly demonstrated that the presence of a FF in IDCs is a very important independent prognostic histological predictor of the outcome of IDC patients by multivariate analyses. Especially, IDC patients with a FF of greater than 8 mm in diameter significantly increased the hazard rates (HRs) of tumor recurrence and distant-organ metastasis in multivariate analyses according to their nodal status or hormone receptor status.The central depressed area CODA) thickness (tumor thickness) of colorectal cancers is an important prognostic parameter for colorectal cancer patients. We 'examined whether the proliferative activities of tumor and stromal components play important roles in tumor thicknes … More s increase and the progression of 157 T3 ulcerative-type colorectal cancers. Colorectal cancers were classified into thin and thick groups according to tumor thickness. The tumor-stromal fibroblast proliferative activity was the only parameter significantly associated with tumor thickness. High tumor-stromal fibroblast proliferative activity showed significant correlations with tumor recurrence in the thin group, and high proliferative activity of tumor-stromal endothelial cells was a significant parameter of tumor recurrence in the thick group in multivariate analyses.IDCs of the breast are composed of stroma-invasive tumors, tumors in lymph vessels and in nodes. We investigated whether the histological characteristics of tumors in vessels and nodes are significantly associated with increased nodal metastases as well as outcomes, in 393 IDO patients. Multivariate analyses showed that, in IDCs without nodal metastasis, FF dimension, and lymph vessel tumor emboli with >6 apoptotic figures and those with a distance from the tumor margin >3 mm had significantly increased the HRs of tumorrecurrence. In IDOs with nodal metastases, apoptotic figures >2 in blood vessel tumors, nodal tumors with mitotic figures >5, those with severe stroma and strand growth, and >5 nodes with extra-nodal invasion significantly increased the HRs of tumor recurrence or death.These above studies firstly demonstrate that tumor-stromal cells in vessels and lymph nodes as well as in primary-invasive tumors play important roles in tumor progression of breast and colorectal cancers in the world. Less

通过回顾性分析证实了乳腺浸润性导管癌（IDC）中纤维化灶（FF）组成的成纤维细胞增殖活性的预后意义。此外，我们前瞻性地研究了439例IDC患者FF的预后意义，并通过多变量分析清楚地表明，IDC中FF的存在是IDC患者预后的一个非常重要的独立预后组织学预测因子。特别是，根据淋巴结状态或激素受体状态，在多变量分析中，FF直径大于8 mm的IDC患者的肿瘤复发和远处器官转移的危险率（HR）显着增加。结直肠癌的中央凹陷区厚度（肿瘤厚度）是结直肠癌患者的重要预后参数。我们研究了肿瘤和间质成分的增殖活性是否在肿瘤厚度中起重要作用。 ...更多信息 的增加和157 T3溃疡型结直肠癌的进展。根据肿瘤厚度将结直肠癌分为薄和厚组。肿瘤间质成纤维细胞增殖活性是与肿瘤厚度显著相关的唯一参数。在多因素分析中，高肿瘤间质成纤维细胞增殖活性与薄组织中肿瘤复发显著相关，高肿瘤间质内皮细胞增殖活性是厚组织中肿瘤复发的重要参数。乳腺IDC由间质浸润性肿瘤、淋巴管肿瘤和淋巴结肿瘤组成。我们在393例IDO患者中研究了血管和淋巴结中肿瘤的组织学特征是否与淋巴结转移的增加以及预后显著相关。多因素分析显示，在无淋巴结转移的IDC中，FF直径、淋巴管瘤栓凋亡数>6和距肿瘤边缘> 3mm的瘤栓与肿瘤复发的HR显著相关。在具有淋巴结转移的IDO中，血管肿瘤中的凋亡图>2，具有核分裂图>5的淋巴结肿瘤，具有严重基质和链生长的那些，以上研究首次证实，血管、淋巴结和原发灶中的肿瘤间质细胞，浸润性肿瘤在世界范围内乳腺癌和结直肠癌的肿瘤进展中起重要作用。少

项目成果

Hasebe T, Morihiro M, Sasaki S, et al.: "Tumor thickness is a histopathological predictive parameter of tumor metastasis and prognosis in patients with Dukes stage Culcerative-type colorectal carcinoma. A two-hospital based study."Cancer. 89. 35-45 (2000)

Hasebe T、Morihiro M、Sasaki S 等人：“肿瘤厚度是 Dukes 期溃疡型结直肠癌患者肿瘤转移和预后的组织病理学预测参数。一项基于两家医院的研究。”癌症。

Hasebe T, Sasaki S, Imoto S, et al.: "Significance of nodal metastatic tumor characteristics in nodal metastasis and prognosis of patients with invasive ductal carcinoma of the breast"Cancer Science. (in print). (2003)

Hasebe T、Sasaki S、Imoto S 等人：“淋巴结转移性肿瘤特征在乳腺浸润性导管癌患者的淋巴结转移和预后中的意义”《癌症科学》。

Hasebe T, Sasaki S, Imoto S, et al.: "Tumor cells in lymph vessel and lymph nodes closely associated with nodal metastasis by invasive ductal carcinoma of the breast."Cancer Science. 94. 508-514 (2003)

Hasebe T、Sasaki S、Imoto S 等人：“淋巴管和淋巴结中的肿瘤细胞与乳腺浸润性导管癌的淋巴结转移密切相关。”《癌症科学》。

Hasebe T, Sasaki S, Imoto S, et al.: "Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast : A prospective study"Modern Pathology. 15. 502-516 (2002)

Hasebe T、Sasaki S、Imoto S 等人：“乳腺浸润性导管癌纤维化病灶的预后意义：一项前瞻性研究”现代病理学。

Hasebe T, Sasaki S, Imoto S, et al.: "Histological characteristics of tumors in blood vessels play an important role in tumor progression of invasive ductal carcinoma of the breast"Cancer Science. (in print). (2003)

Hasebe T、Sasaki S、Imoto S 等人：“血管肿瘤的组织学特征在乳腺癌浸润性导管癌的肿瘤进展中发挥着重要作用”《癌症科学》。