Functional analysis of dockkopf 3 in liver development and regeneration

ockkopf 3在肝脏发育和再生中的功能分析

• 批准号: 21590414
• 负责人: KANO Junko
• 金额: $ 3万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590414/
• 关键词: 肝臓; 細胞; がん関連遺伝子; 発生; 分化; シグナル伝達

To elucidate the function of Dickkopf 3 (Dkk3), a possible regulator in liver development and regeneration, we have investigated the molecular mechanism of anti-apoptotic function in Dkk3-overexpressing cells, the receptor of Dkk3, and the contribution to liver regeneration in Dkk3-knockout mice. In result, it was revealed that the suppression of reactive oxygen species was involved in the anti-apoptotic function, and possible candidates for the receptors were found. On the other hand, no significant contribution was shown in the analysis using Dkk3-knockout mouse model.

为了阐明Dickkopf 3（Dkk3）在肝脏发育和再生中的可能调节因子的功能，我们研究了Dkk3过表达细胞中抗凋亡功能的分子机制、Dkk3的受体以及Dkk3敲除小鼠对肝脏再生的贡献。结果表明，活性氧的抑制参与了抗细胞凋亡的功能，并发现了可能的受体候选者。另一方面，使用Dkk3基因敲除小鼠模型的分析没有显示出显著的贡献。

项目成果

Dickkopf3の抗アポトーシス機序の解明

Dickkopf3抗凋亡机制的阐明

• 发表时间: 2011
• 作者: 加野准子;他4名
• 通讯作者: 他4名

Establishment of hepati c stem-like cell lines from normal a dult porcine liver in a poly-D-lysine coateddish with NAIR-1 medium

在含有 NAIR-1 培养基的聚 D-赖氨酸包被培养皿中建立来自正常成年猪肝脏的肝干样细胞系

• 发表时间: 2010
• 作者: 幅野渉;他;Junko Kano
• 通讯作者: Junko Kano

High expression of stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinoma

• DOI: 10.1002/ijc.25907
• 发表时间: 2011-11-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Shiba-Ishii, Aya;Kano, Junko;Noguchi, Masayuki
• 通讯作者: Noguchi, Masayuki

APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway

APAF-1 与睾丸生殖细胞肿瘤途径的未分化状态相关

• DOI: 10.1111/j.1349-7006.2010.01750.x
• 发表时间: 2011
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: Behjati R;Kano J;Noguchi M;et al.
• 通讯作者: et al.

Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas

• DOI: 10.1007/s00428-009-0772-4
• 发表时间: 2009-05
• 期刊: Virchows Archiv
• 影响因子: 3.5
• 作者: Yihua Pei;J. Kano;T. Iijima;Y. Morishita;Y. Inadome;M. Noguchi