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Functional analysis of dockkopf 3 in liver development and regeneration

Functional analysis of dockkopf 3 in liver development and regeneration
ockkopf 3在肝脏发育和再生中的功能分析
批准号:
21590414
负责人:
KANO Junko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To elucidate the function of Dickkopf 3 (Dkk3), a possible regulator in liver development and regeneration, we have investigated the molecular mechanism of anti-apoptotic function in Dkk3-overexpressing cells, the receptor of Dkk3, and the contribution to liver regeneration in Dkk3-knockout mice. In result, it was revealed that the suppression of reactive oxygen species was involved in the anti-apoptotic function, and possible candidates for the receptors were found. On the other hand, no significant contribution was shown in the analysis using Dkk3-knockout mouse model.
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Dickkopf3の抗アポトーシス機序の解明
Dickkopf3抗凋亡机制的阐明
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [加野准子, 他4名]
通讯作者: 他4名
Establishment of hepati c stem-like cell lines from normal a dult porcine liver in a poly-D-lysine coateddish with NAIR-1 medium
在含有 NAIR-1 培养基的聚 D-赖氨酸包被培养皿中建立来自正常成年猪肝脏的肝干样细胞系
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [幅野渉, 他, Junko Kano]
通讯作者: Junko Kano
DOI: 10.1002/ijc.25907
发表时间: 2011-11-15
期刊: INTERNATIONAL JOURNAL OF CANCER
影响因子: 6.4
作者: [Shiba-Ishii, Aya, Kano, Junko, Noguchi, Masayuki]
通讯作者: Noguchi, Masayuki
APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway
APAF-1 与睾丸生殖细胞肿瘤途径的未分化状态相关
DOI: 10.1111/j.1349-7006.2010.01750.x
发表时间: 2011
期刊: Cancer Science
影响因子: 5.7
作者: [Behjati R, Kano J, Noguchi M, et al.]
通讯作者: et al.
12
    Functional analysis of differentially expressed genes in hepatic stem cells and the application to the diagnosis of chronic hepatitis and liver cirrhosis.
    • 批准号:
      17590335
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      KANO Junko
    • 依托单位:
    Analysis of differentially expressed genes in hepatic stem-like cells by cDNA subtraction.
    • 批准号:
      14570178
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2002
    • 负责人:
      KANO Junko
    • 依托单位:
    国内基金
    海外基金
    维生素B6调控IL-33泛素化在二型先天性淋巴細胞(ILC2)介导的呼吸道炎症反应中作用机制研究