Functional analysis of dockkopf 3 in liver development and regeneration
Functional analysis of dockkopf 3 in liver development and regeneration
批准号:
21590414
负责人:
KANO Junko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
To elucidate the function of Dickkopf 3 (Dkk3), a possible regulator in liver development and regeneration, we have investigated the molecular mechanism of anti-apoptotic function in Dkk3-overexpressing cells, the receptor of Dkk3, and the contribution to liver regeneration in Dkk3-knockout mice. In result, it was revealed that the suppression of reactive oxygen species was involved in the anti-apoptotic function, and possible candidates for the receptors were found. On the other hand, no significant contribution was shown in the analysis using Dkk3-knockout mouse model.
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Dickkopf3の抗アポトーシス機序の解明
Dickkopf3抗凋亡机制的阐明
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[加野准子, 他4名]
通讯作者:
他4名
Establishment of hepati c stem-like cell lines from normal a dult porcine liver in a poly-D-lysine coateddish with NAIR-1 medium
在含有 NAIR-1 培养基的聚 D-赖氨酸包被培养皿中建立来自正常成年猪肝脏的肝干样细胞系
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[幅野渉, 他, Junko Kano]
通讯作者:
Junko Kano
DOI:
10.1002/ijc.25907
发表时间:
2011-11-15
期刊:
INTERNATIONAL JOURNAL OF CANCER
影响因子:
6.4
作者:
[Shiba-Ishii, Aya, Kano, Junko, Noguchi, Masayuki]
通讯作者:
Noguchi, Masayuki
APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway
APAF-1 与睾丸生殖细胞肿瘤途径的未分化状态相关
DOI:
10.1111/j.1349-7006.2010.01750.x
发表时间:
2011
期刊:
Cancer Science
影响因子:
5.7
作者:
[Behjati R, Kano J, Noguchi M, et al.]
通讯作者:
et al.
DOI:
10.1007/s00428-009-0772-4
发表时间:
2009-05
期刊:
Virchows Archiv
影响因子:
3.5
作者:
[Yihua Pei;J. Kano;T. Iijima;Y. Morishita;Y. Inadome;M. Noguchi]
通讯作者:
Yihua Pei;J. Kano;T. Iijima;Y. Morishita;Y. Inadome;M. Noguchi
共 12 条
Functional analysis of differentially expressed genes in hepatic stem cells and the application to the diagnosis of chronic hepatitis and liver cirrhosis.
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批准号:17590335
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:KANO Junko
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依托单位:
Analysis of differentially expressed genes in hepatic stem-like cells by cDNA subtraction.
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批准号:14570178
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:KANO Junko
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依托单位:
国内基金
海外基金
维生素B6调控IL-33泛素化在二型先天性淋巴細胞(ILC2)介导的呼吸道炎症反应中作用机制研究
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批准号:32000667
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2020
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负责人:张亚光
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依托单位: