Spatiotemporal pathophysiology of systemic immunological disorders and autoimmune arthritis caused by aberrant cytokine signaling

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A model mouse for rheumatoid arthritis, gp130F759 exhibited increases of serum cytokines and autoantibodies, and infiltration of inflammatory cells in the synovium at 5-month-old, when the clinical arthritis is hardly detectable. Furthermore, increased tyrosine-phosphorylation of STAT3, as an aberrant gp130 signaling, and production of Padi4 protein that may involve in the autoantibody production, were detected in the joints. We found the earliest changes in the joints of gp130F759, which is informative for the understanding of the early pathophysiology of rheumatoid arthritis.