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A study of the effect of a recombinant immunosuppressive factor from parasites and immune-inhibitory mechanisms

A study of the effect of a recombinant immunosuppressive factor from parasites and immune-inhibitory mechanisms
重组寄生虫免疫抑制因子的作用及免疫抑制机制研究
批准号:
21590464
负责人:
FUKUMOTO Soji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
An immunosuppressive factor(ES90) from Spirometra erinaceieuropaei plerocercoids was cloned and the recombinant ES90 was synthesized using wheat germ cell free expression system. However, the recombinant ES90 did not inhibit nitric oxide production in macrophages. Messenger RNA of Ym1, FIZZ1, and arginase 1 were expressed in peritoneal macrophages from Trichinella spiralis-infected mice. In connection with this, 2 types of peroxiredoxin(Prx) from T. spiralis were cloned, Prx-1 mRNA expression was stage-specific
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会议论文
旋毛虫の新生幼虫によるマウス腹腔マクロファージのAlternative activation
新生旋毛虫幼虫对小鼠腹腔巨噬细胞的替代激活
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [井上菜菜瀬, 福本宗嗣, 大槻均, 入子英幸]
通讯作者: 入子英幸
Functional analysis of an immunosuppressive factor secreted from a parasite and its application to rheumatoid arthritis model
  • 批准号:
    19590427
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2007
  • 负责人:
    FUKUMOTO Soji
  • 依托单位:
Research on a parasite factor suppressing the gene expression of TNF-α and chemokines in macrophages
  • 批准号:
    13670246
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.3万
  • 财政年份:
    2001
  • 负责人:
    FUKUMOTO Soji
  • 依托单位:
Studies on the suppressive factor from parasite of NO synthase and cytokine gene expression in macrophages
  • 批准号:
    11670241
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.3万
  • 财政年份:
    1999
  • 负责人:
    FUKUMOTO Soji
  • 依托单位:
Effects of parasites on the gene expression of nitric oxide synthase and cytokine in macrophages
  • 批准号:
    09670259
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.98万
  • 财政年份:
    1997
  • 负责人:
    FUKUMOTO Soji
  • 依托单位:
海外基金