Spread and pathogenecity of PVL-positive MRSA strains emerging in the community

社区中出现的 PVL 阳性 MRSA 菌株的传播和致病性

• 批准号: 21590493
• 负责人: ITO Teruyo
• 金额: $ 3万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590493/
• 关键词: MRSA; PVL; 遺伝子; 病原性; ラテックス凝集反応; Cell; 市中感染型MRSA

The majority of MRSA strains isolated from outpatients of dermatology carried types IV or V SCCmec elements, which are characteristic in community-acquired MRSA strains. PVL positive isolates were roughly classified into two, the international clones that might be imported from other countries, e. g., US, India, or Taiwan, and the domestic clones.Two novel PVL phages belonging to group 3 siphoviridae were identified in two international clones, ST59 and ST772. Titers of anti-PVL as well as anti-staphylococcus aureus antibodies in the sera of children were lower than those of adults, suggesting that it might be a reason that life-threatening infection was occurred among children.

从皮肤科门诊患者分离的MRSA菌株大多数携带IV型或V型SCCmec元素，这是社区获得性MRSA菌株的特征。PVL阳性分离株大致分为两类，一类是可能从其他国家（如美国、印度或台湾）输入的国际克隆，另一类是国内克隆。在ST59和ST772两个国际克隆中鉴定出2个新型PVL噬菌体，属于siphoviridae 3族。儿童血清抗pvl和抗金黄色葡萄球菌抗体滴度低于成人，提示这可能是儿童发生危及生命的感染的原因之一。

项目成果

The organization of genomes of PVL-carrying phages

携带PVL的噬菌体基因组的组织

• 发表时间: 2010
• 作者: Teruyo Ito;Moe Cho;Xiao Han;Keiichi Hiramatsu
• 通讯作者: Keiichi Hiramatsu

Organization of genomes of PVL-carrying phages

携带PVL的噬菌体基因组的组织

• 发表时间: 2010
• 作者: Meng Zhang;Teruyo Ito;Shanshuang Li;Keiichi Hiramatsu
• 通讯作者: Keiichi Hiramatsu

Identification of novel leukocidin/haemolysin toxin family proteinds, MW1941 and MW1942, in Staphylococcus aureus

金黄色葡萄球菌中新型杀白细胞素/溶血素毒素家族蛋白 MW1941 和 MW1942 的鉴定

• 发表时间: 2011
• 作者: Hongo;I;et al
• 通讯作者: et al

Trial to control an outbreak of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus at a boarding school in Japan

• DOI: 10.1016/j.ajic.2011.02.010
• 发表时间: 2011-12-01
• 期刊: AMERICAN JOURNAL OF INFECTION CONTROL
• 影响因子: 4.9
• 作者: Higashiyama, Masaaki;Ito, Teruyo;Kawana, Akihiko
• 通讯作者: Kawana, Akihiko

Identification of a novel subtype of type V SCCmec among strains negative in the BD GeneOhm^<TM> MRSA assay

BD GeneOhm^<TM> MRSA 检测阴性菌株中 V 型 SCCmec 的新亚型的鉴定

• 发表时间: 2011
• 作者: Teruyo ITO;Meng ZHANG;et al
• 通讯作者: et al