Thalamo-cortical circuitry in PVL
PVL 中的丘脑皮质回路
基本信息
- 批准号:10681328
- 负责人:
- 金额:$ 42.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAffectAnisotropyAnteriorAtlasesAtrophicBehaviorBehavioralBilateralBiological MarkersBrainBrain Hypoxia-IschemiaBrain InjuriesCell NucleusCerebral cortexCharacteristicsCommunicationComplexDataDevelopmentDiffuseDiffusionDiffusion Magnetic Resonance ImagingFunctional Magnetic Resonance ImagingFutureGenderGeniculate body structureGoalsHabilitationHistologicImageImpairmentIndividualInfantInjuryInterventionLinkLong-Term EffectsMagnetic Resonance ImagingMapsMeasuresMethodologyModalityModelingMyelinOligodendrogliaOutcomeOutcome MeasureParentsPerinatal HypoxiaPeriventricular LeukomalaciaPersonsPredispositionPremature InfantProcessPulvinar structureRegression AnalysisResolutionRestRetrograde DegenerationSeriesSeveritiesSurvivorsTestingThalamic NucleiThalamic structureTherapeuticVisionVisualVisual impairmentWaterage effectbehavioral outcomecohortevidence basegray matterhypoxic ischemic injuryinsightmorphometrymultimodal neuroimagingmultimodalitymyelinationneuroimagingneuron losspreservationprognosticrecruitsegregationtractographyvisual dysfunctionvisual processingwhite matterwhite matter injury
项目摘要
Project Summary/Abstract
Infants born prematurely are predisposed to hypoxic-ischemic (HI) injury such as periventricular leukomalacia
(PVL), resulting in developmental disturbances to the thalamus, white matter, and cerebral cortex. As a
consequence, survivors of PVL frequently demonstrate visual impairments to varying degrees. Because the
thalamus is critical to visual processing, visual dysfunctions may be more severe if the thalamus is affected as
a consequence of the HI insult. Yet, the effects of PVL on the developing thalamo-cortical network are unclear.
In particular, it is currently not known how aberrant thalamo-cortical connectivity or altered volume of thalamic
nuclei contribute to the deficits in visual processing that are commonly observed in individuals with PVL. To
this end, the overall goal of the current study is to address the hypothesis that visual perceptual processing
deficits may be more severe in individuals with PVL who have decreased volume of visual thalamic nuclei,
distinct changes in myelination of thalamo-cortical networks, or atypical thalamo-cortical connectivity. We have
developed a cutting-edge multimodal MRI approach consisting of morphometric analysis of individual thalamic
nuclei, diffusion kurtosis imaging (DKI), high angular resolution diffusion imaging (HARDI), myelin water
fraction maps, and network connectivity analyses that will be used in conjunction with a battery of tests of
visual perceptual functions to determine the link between thalamic neuronal loss, thalamo-cortical connectivity,
and visual perceptual processing abilities. A total of 36 individuals with PVL will be recruited, along with a
cohort of 36 typically-developing controls. A rigorous statistical plan will use multiple levels of analysis to
investigate the differences in behavioral and neuroimaging variables between individuals with PVL and
controls, as well as the correlation between outcome measures. A series of regression analyses will evaluate
the associations of neuroimaging variables with PVL and functional vision. Models will also consider the effects
of age and gender on neuroimaging and behavioral outcomes. The unique combination of neuroimaging
modalities utilized in this proposed study will provide complementary insight regarding the complex interplay
between preterm HI damage in PVL and the resulting changes in thalamic development, and ultimately relate
these findings to visual perceptual deficits. This study will contribute to our understanding of the impact of PVL
on the establishment and myelination of the thalamo-cortical networks involved with visual perceptual
processes, providing evidence-based biomarkers that can be used to evaluate future therapeutic approaches.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Corinna M Bauer其他文献
Microvascular obstruction in patients with non-ST-elevation myocardial infarction: a contrast-enhanced cardiac magnetic resonance study
非 ST 段抬高型心肌梗死患者的微血管阻塞:对比增强心脏磁共振研究
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
E. Guerra;M. Hadamitzky;G. Ndrepepa;Corinna M Bauer;T. Ibrahim;I. Ott;K. Laugwitz;H. Schunkert;A. Kastrati - 通讯作者:
A. Kastrati
Corinna M Bauer的其他文献
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