Regulation of genome replication of negative-strand RNA virus by an accessory protein

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Infection experiments with the C protein-deficient Sendai virus, which has a single-stranded negative-sense RNA as a genome, suggested that the C protein was involved in regulation of RNA genome polarity during genome replication. The C protein appeared to suppress genomic RNA synthesis in a promoter-dependent fashion, resulting that progeny viruses dominantly had a negative-sense RNA genome. This regulation seems to be related with interferon-βinduction. We also tested other closely related viruses for the regulation.