Molecular Mechanisms of Establishment, Maintenance and Breakdown of Viral Persistent Infection

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We tried to devise a quantitative method for analyzing establishing-efficiency of persistent viral infection. Subsequently, we analyzed factors of Sendai virus contributing to persistent infection by applying the quantitative method, indicating that L protein plays a determinative role in establishment of and M protein has an additional ability to induce persistent infection Fpi protein also contributes to persistent viral infection, but HNpi protein shows suppressive effect on establishment of persistent viral infection. HPIV2 induced cell toxicity, that is, giant cell formation, was suppressed by Rho kinase inhibitor, indicating that Rho kinase plays a positive role in HPIV2 induced cell toxicity and C kinase inhibitor enhanced HPIV2 induced cell toxicity. Intriguingly, the protein kinases showed intracellular networks.