Molecular mechanism of lymphocyte activation by a novel CDM-family protein.

新型 CDM 家族蛋白激活淋巴细胞的分子机制。

• 批准号: 21590537
• 负责人: TANAKA Yoshihiko
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590537/
• 关键词: 免疫学; シグナル伝達; 細胞・組織; 発生・分化; 脳神経疾患; 細胞/組織; 発生/分化; 細胞; 組織; 発生; 分化

A novel CDM庸amily protein was studied for molecular mechanism of lymphocyte activation and guanine nucleotide exchange factors. The numbers of T cells in the spleen and the peripheral lymph nodes were reduced in the gene妖eficient mice. Also, antigen耀pecific T幼ell proliferation was impaired in the gene妖eficient mice. Finally, the novel CDM庸amily protein functioned as a Cdc42耀pecific guanine nucleotide exchange factor.

A novel CDM family protein was studied for molecular mechanism of lymphocyte activation and guanine nucleotide exchange factors. The numbers of T cells in the spleen and the peripheral lymph nodes were reduced in the gene demon efficient mice. Also, antigen specific T cell proliferation was imprinted in the gene demon efficient mice. Finally, the novel CDM family protein functioned as a Cdc42 specific guanine nucleotide exchange factor.

项目成果

Critical role of DOCK2 in type I IFN induction in plasmacytoid dendritic cells.

DOCK2 在浆细胞样树突状细胞中 I 型 IFN 诱导中的关键作用。

• 发表时间: 2010
• 作者: Gotoh K;et al
• 通讯作者: et al

Critical Role of DOCK2 in Type I IFI￥Induction in Plasmacytoid Dendritic cells

DOCK2 在浆细胞样树突状细胞 I 型 IFI￥诱导中的关键作用

• 发表时间: 2009
• 作者: Gotoh K.;Tanaka Y.;Nishikimi A.;Nakamura R.;Yamada H.;Higashi S.;Uru no T.;Yoshikai Y.;and Fukui Y.
• 通讯作者: and Fukui Y.

Identification of a signaling molecule critical for dendritic cell migration in three-dimensional environments

鉴定对三维环境中树突状细胞迁移至关重要的信号分子

• 发表时间: 2012
• 作者: Harada Y;et al
• 通讯作者: et al

免疫系特異的なRac活性化因子DOCK2を標的とした免疫抑制剤の開発

开发针对免疫系统特异性 Rac 激活剂 DOCK2 的免疫抑制剂

• 发表时间: 2012
• 作者: 錦見昭彦;田中芳彦;福井宣規
• 通讯作者: 福井宣規

自然免疫システムにおけるDOCK2の機能とその制御

DOCK2在先天免疫系统中的功能及其调节

• 发表时间: 2010
• 期刊: 細胞工学
• 作者: 田中芳彦;他
• 通讯作者: 他