Evaluation of dendritic cells(DCs) in the regulation of memory T cells

树突状细胞（DC）对记忆T细胞调节的评价

• 批准号: 21590546
• 负责人: FUJII Shin-ichiro
• 金额: $ 3万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590546/
• 关键词: 記憶免疫; 自然免疫; 樹状細胞; NKT細胞; 免疫監視; 腫瘍免疫

To induce not only effector T cells, but also memory T cells is important issue for an establishment of immune defense against infectious and cancer diseases. There are many reports of memory T cells in some viral infectious diseases, however to induce anti-tumor T cell effects against tumor associated antigen has not been studied well, due to the low amounts of antigen expression on tumor cells. We previously demonstrated that our strategy using NKT ligand loaded tumor cells showed long term antitumor effects. In the current study, we analyzed the kinetics of memory T cells and elucidated the mechanism of the induction of memory T cells.

诱导效应T细胞和记忆T细胞是建立抗感染性和肿瘤疾病免疫防御的重要问题。记忆T细胞在一些病毒性感染性疾病中有许多报道，但由于肿瘤细胞上的抗原表达量很少，因此诱导抗肿瘤T细胞对肿瘤相关抗原的抗肿瘤作用尚未得到很好的研究。我们之前证明了我们使用NKT配体负载肿瘤细胞的策略显示出长期的抗肿瘤作用。在本研究中，我们分析了记忆T细胞的动力学，阐明了记忆T细胞的诱导机制。

项目成果

Development of anti-tumor artificial adjuvant vector cells linking innate and adaptive immunity

连接先天免疫和适应性免疫的抗肿瘤人工佐剂载体细胞的开发

• 发表时间: 2011
• 作者: Shimizu K;Asakura M;Sugahara H;Shinga J;Fujii S
• 通讯作者: Fujii S

New type of immunotherapy using artificial adjuvant vector cells(aAVCs) linking innate and adaptive immunity

使用人工佐剂载体细胞（aAVC）连接先天免疫和适应性免疫的新型免疫疗法

• 发表时间: 2011
• 作者: 多根(橋本)彰子;横須賀忠;斉藤隆;Fujii S
• 通讯作者: Fujii S

iNKT cell-triggered in vivo DC targeting immunotherapy. "Recent advances in immune regulation and immunotherapy"

iNKT 细胞触发的体内 DC 靶向免疫治疗。

• 发表时间: 2010
• 作者: Fujii;S
• 通讯作者: S

Antigen mRNA-transfected, fibroblasts loaded with invariant NKT cell ligand act as adjuvant vector to target in vivo dendritic cells(DCs)

抗原 mRNA 转染，负载不变 NKT 细胞配体的成纤维细胞作为佐剂载体靶向体内树突状细胞 (DC)

• 发表时间: 2010
• 作者: Fujii S;Asakura M;Shimizu K
• 通讯作者: Shimizu K

NKT細胞と樹状細胞のクロストーク

NKT 细胞和树突状细胞之间的串扰

• 发表时间: 2009
• 作者: Tashiro T;Nakagawa R;Hirokawa T;Inoue S;Watarai H;Taniguchi M;Mori K.;藤井眞一郎
• 通讯作者: 藤井眞一郎