Evaluation of dendritic cells(DCs) in the regulation of memory T cells

不仅诱导效应性T细胞，而且诱导记忆性T细胞对于建立针对传染病和癌症疾病的免疫防御是重要的问题。记忆性T细胞在病毒感染性疾病中的应用已有很多报道，但由于肿瘤细胞上抗原表达量低，因此其诱导抗肿瘤T细胞效应的研究尚不深入。我们先前证明，我们使用NKT配体负载的肿瘤细胞的策略显示出长期的抗肿瘤作用。在本研究中，我们分析了记忆T细胞的动力学，并阐明了记忆T细胞的诱导机制。

To induce not only effector T cells, but also memory T cells is important issue for an establishment of immune defense against infectious and cancer diseases. There are many reports of memory T cells in some viral infectious diseases, however to induce anti-tumor T cell effects against tumor associated antigen has not been studied well, due to the low amounts of antigen expression on tumor cells. We previously demonstrated that our strategy using NKT ligand loaded tumor cells showed long term antitumor effects. In the current study, we analyzed the kinetics of memory T cells and elucidated the mechanism of the induction of memory T cells.