Elucidation of the source of pluripotent progenitor cells in systemic inflammatory mouse model
Elucidation of the source of pluripotent progenitor cells in systemic inflammatory mouse model
批准号:
21590589
负责人:
YAMAMOTO Seiji
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
在全身炎症反应综合征中,在损伤的肺中观察到成髓细胞。为了阐明多能祖细胞(成髓细胞)是否分化为肺泡II型细胞或支持肺泡细胞在脓毒症中存活。我们证明了多能祖细胞通过CD 34表达分为2个亚群。虽然CD 34 ^+亚群具有较强的吞噬活性,但CD 34 ^-亚群可能具有肺泡保护作用。
英文摘要
In systemic inflammatory response syndrome, myeloblasts are observed in injured lung. To elucidate, whether pluripotent progenitor cells(myeloblasts) differentiate to alveolar type II cells or support to survive of the alveolar cells in sepsis. We demonstrated that pluripotent progenitors were classified 2 subsets by CD34 expression. Although CD34^+subset showed strong phagocytic activity, CD34^-subset may have alveo-protective effect.
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マウス脳血管内皮細胞株を用いたEndothelial microparticles(EMP)のin vitro産生系の確立および疾患バイオマーカーとしての可能性の検討
使用小鼠脑血管内皮细胞系建立内皮微粒(EMP)体外生产系统并研究其作为疾病生物标志物的潜力
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山本誠士, 他]
通讯作者:
他
NG2 positive cerebral microvascular pericytes are potentially derived from circulating myeloid progenitors.
NG2 阳性脑微血管周细胞可能源自循环骨髓祖细胞。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamamoto S, 他]
通讯作者:
他
DOI:
10.1159/000272952
发表时间:
2010-01-01
期刊:
PATHOBIOLOGY
影响因子:
5
作者:
[Miyamoto, Satoshi, Cooper, Lyndon, Saito, Ichiro]
通讯作者:
Saito, Ichiro
Impact of transcription factor decoy to AP-1 on the Lung apoptosis of septic mice.
AP-1 转录因子诱饵对脓毒症小鼠肺细胞凋亡的影响。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Matsuda N, Hattori Y, Yamamoto S, Yamazaki H, Koike K]
通讯作者:
Koike K
Endotheiial microparticles(EMP)のin vitro産生系の確立およびin vivo病態モデルでの解析
建立内皮微粒(EMP)体外生产系统并使用体内疾病模型进行分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山本誠士, 東英梨月, 村松昌, 宮崎賢治, 佐竹美芽, 堂本光子, 新飯田俊平, 服部裕一]
通讯作者:
服部裕一
共 59 条
Newly developed intravital fluorescence imaging in deep brain regions for translational research
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批准号:24659648
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
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负责人:YAMAMOTO Seiji
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依托单位:
Endothelial microparticles modulate cellular status of pericytes
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批准号:24659112
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2012
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负责人:YAMAMOTO Seiji
-
依托单位:
The study of neuroprotection and the mitochondrial protein UCP4 induced by electrical stimulation of the brain
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批准号:23390345
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
-
财政年份:2011
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负责人:YAMAMOTO Seiji
-
依托单位:
The study to reveal the neuroprotective mechanisms induced by electrical stimulation of the brain
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批准号:20390380
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.56万
-
财政年份:2008
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负责人:YAMAMOTO Seiji
-
依托单位:
Newly developed intravital cell imaging and its application for brain science
-
批准号:16390407
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.26万
-
财政年份:2004
-
负责人:YAMAMOTO Seiji
-
依托单位:
Single molecule analysis for nuclear DNAof the neuron in excitotoxicity
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批准号:14571306
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2002
-
负责人:YAMAMOTO Seiji
-
依托单位:
The study for imaging, in vivo, brain mitochondrial. dysfunction using positron emission tomography
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批准号:13557116
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.55万
-
财政年份:2001
-
负责人:YAMAMOTO Seiji
-
依托单位:
The role of mitochondrial dysfunction in the process of glutamate neurotoxicity
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批准号:10671292
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:1998
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负责人:YAMAMOTO Seiji
-
依托单位:
海外基金