Endothelial microparticles modulate cellular status of pericytes

我们在体外研究了炎症内皮细胞产生的内皮微粒(EMPs)。对EMPs进行掺入研究，并在EMPs作用下利用周细胞分析mRNA和蛋白的表达水平。在这里，我们显示EMPs含有炎性特异性miRNA。EMPs掺入周细胞后，其转录和蛋白表达水平均发生改变。我们发现EMPs的靶细胞是周细胞，提示EMPs中的EMPs和miRNA是各种炎症性疾病的新治疗靶点。

We studied endothelial microparticles (EMPs) produced from inflamed endothelial cells in vitro. EMPs incorporation study was performed, and mRNA and protein expression levels were analyzed using pericytes by the action of the EMPs. Here we show that EMPs contained inflammatory specific miRNA. EMPs incorporated pericytes were altered their transcription and protein expression levels. We have shown that target cells of EMPs are pericytes, suggesting EMPs and miRNA included in the EMPs are new therapeutic target of the various inflammatory diseases.