The study to reveal the neuroprotective mechanisms induced by electrical stimulation of the brain
The study to reveal the neuroprotective mechanisms induced by electrical stimulation of the brain
批准号:
20390380
负责人:
YAMAMOTO Seiji
金额:
$11.56万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We tried to reveal the neuroprotective mechanisms induced by the electrical stimulation of cerebellar fastigial nucleus (FN) in rats. 1h-FN stimulation decreased, 72h later, the infarct volume by 22%. 1h-FN stimulation increased, 72h later, mRNA level of uncoupling protein 4 (UCP4), a mitochondria protein, to 160% in the brain. Intra-ventricular injection of siRNA decreased the UCP4 mRNA level, and tended to abolish the neuroprotection induced by FN stimulation. Following FN stimulation, up-regulation of UCP4 may be a component of the endogenous neuroprotective mechanisms.
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Real-time intravital imaging of hydroxyl radical (・OH) production upon neuroprotection of radical scavenger in rat hippocampus
自由基清除剂对大鼠海马神经保护作用下羟自由基(·OH)产生的实时活体成像
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[山本清二, et al.]
通讯作者:
et al.
CIF-0173 protects against cerebral infarction through DP1 receptor activation.
CIF-0173 通过 DP1 受体激活预防脑梗塞。
DOI:
--
发表时间:
2009
期刊:
Exp Neurology 219
影响因子:
--
作者:
[Thura M, Hokamura K, Yamamoto S, et al.]
通讯作者:
et al.
Physiological and pathological calcium responses in the deep brain regions observed with fiber-coupled confocal microscope
光纤耦合共聚焦显微镜观察大脑深部区域的生理和病理钙反应
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yamamoto S, et al.]
通讯作者:
et al.
グリオトキシンは海馬CA3神経細胞の-過性前脳虚血に対する脆弱性を増強する(Gliotoxin decreases neuronal viability following transient forebrain ischemia in CA3 hippocampus)
胶霉毒素增加海马 CA3 神经元对短暂前脑缺血的脆弱性(胶霉毒素降低海马 CA3 短暂前脑缺血后神经元的活力)
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[山本清二, 他]
通讯作者:
他
Intravital Oxygen Radical Imaging in Normal and Ischemic Rat Cortex
正常和缺血大鼠皮层的活体氧自由基成像
DOI:
10.1227/01.neu.0000370055.99998.6b
发表时间:
2010-07-01
期刊:
NEUROSURGERY
影响因子:
4.8
作者:
[Wang, Yong, Yamamoto, Seiji, Terakawa, Susumu]
通讯作者:
Terakawa, Susumu
共 9 条
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The study of neuroprotection and the mitochondrial protein UCP4 induced by electrical stimulation of the brain
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Newly developed intravital cell imaging and its application for brain science
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The role of mitochondrial dysfunction in the process of glutamate neurotoxicity
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负责人:YAMAMOTO Seiji
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海外基金