Remodeling of lymph vessels in the fibrotic lesion of bronchioloalveolar cell carcinoma

细支气管肺泡细胞癌纤维化病变中淋巴管的重塑

• 批准号: 21590619
• 负责人: HONDA Takayuki
• 金额: $ 2.83万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590619/
• 关键词: 肺癌; 肺腺癌; リンパ管; リンパ管侵襲; 腺癌; 肺; 気管支肺胞上皮癌; 線維化

The aim of this study is to clear three-dimensional morphological changes of lymphatic vessels in a progression of BAC. In the normal alveolar region, they straightly elongated without bifurcation and most of them were compressed. In the central portion of the fibrotic lesion, the density of lymph vessels was higher and the lumens were wider. The lymph vessels morphologically changed to a tank. As the BAC advances forming central fibrosis, the volume ratio of the lymph vessels to the whole one of the cancer will become larger, and probability of carcinoma cell invasion to the lymph vessels will increase.

本研究的目的是明确淋巴管在BAC进展过程中的三维形态变化。在正常牙槽区，它们呈直线伸长，无分叉，大部分受压。纤维性病变中央淋巴管密度较高，管腔较宽。淋巴管在形态上变成了一个储罐。随着BAC形成中心性纤维化，淋巴管体积比增大，癌细胞向淋巴管侵袭的几率增加。

项目成果

A novel device (SD-101) with high accuracy for screening sleep apnoea-hypopnoea syndrome

• DOI: 10.1111/j.1440-1843.2009.01627.x
• 发表时间: 2009-11-01
• 期刊: RESPIROLOGY
• 影响因子: 6.9
• 作者: Agatsuma, Toshihiko;Fujimoto, Keisaku;Nomiyama, Tetsuo
• 通讯作者: Nomiyama, Tetsuo

Malignant Hepatic Epithelioid Hemangioendothelioma with Rapid Progression and Fatal Outcome

• DOI: 10.2169/internalmedicine.49.3148
• 发表时间: 2010-01-01
• 期刊: INTERNAL MEDICINE
• 影响因子: 1.2
• 作者: Komatsu, Yoshimichi;Koizumi, Tomonobu;Hachiya, Tsutomu
• 通讯作者: Hachiya, Tsutomu

HRCT Features of Small Peripheral Lung Carcinomas Detected in a Low-dose CT Screening Program

• DOI: 10.1016/j.acra.2009.08.003
• 发表时间: 2010-01-01
• 期刊: ACADEMIC RADIOLOGY
• 影响因子: 4.8
• 作者: Sone, Shusuke;Matsumoto, Toru;Haniuda, Masayuki
• 通讯作者: Haniuda, Masayuki

Comparative Study of Three Different Catheters for CT Imaging-Bronchoscopy-Guided Radiofrequency Ablation as a Potential and Novel Interventional Therapy for Lung Cancer

• DOI: 10.1378/chest.09-1065
• 发表时间: 2010-04-01
• 期刊: CHEST
• 影响因子: 9.6
• 作者: Tanabe, Tsuyashi;Koizumi, Tomonobu;Yoshida, Kazuo
• 通讯作者: Yoshida, Kazuo