Remodeling of lymph vessels in the fibrotic lesion of bronchioloalveolar cell carcinoma

本研究的目的是明确淋巴血管在BAC进展中的三维形态学变化。正常肺泡区呈直长型，无分岔，且多受压。在纤维化灶的中心部位，淋巴管密度较高，管腔较宽。淋巴管在形态上变成了一个容器。随着BAC的进展形成中枢性纤维化，淋巴管与肿瘤整体的体积比增大，癌细胞侵袭淋巴管的概率增大。

The aim of this study is to clear three-dimensional morphological changes of lymphatic vessels in a progression of BAC. In the normal alveolar region, they straightly elongated without bifurcation and most of them were compressed. In the central portion of the fibrotic lesion, the density of lymph vessels was higher and the lumens were wider. The lymph vessels morphologically changed to a tank. As the BAC advances forming central fibrosis, the volume ratio of the lymph vessels to the whole one of the cancer will become larger, and probability of carcinoma cell invasion to the lymph vessels will increase.