Development of epigenetic factors for the prognosis of autoimmune thyroid disease using monozygotic twins
Development of epigenetic factors for the prognosis of autoimmune thyroid disease using monozygotic twins
批准号:
21590625
负责人:
WATANABE Mikio
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We have collected genomic DNA samples from patients with autoimmune thyroid diseases who were strictly classified into categories depend on their prognosis, and also from monozygotic twin pairs. We have clarified the associations of some functional polymorphisms in immune regulatory genes with the prognosis of Graves' and Hashimoto' s diseases. In addition, we have reported for the first time that the global methylation of genomic DNA was related to the genotype of polymorphism in DNMT1 gene, which also associated with the prognosis of autoimmune thyroid diseases.
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Prolonged hybridization with a cRNA probe improves the signal to noise ratio for in-tube in situ hybridization for quantification of mRNA after fluorescence-activated cell sorting
与 cRNA 探针的长时间杂交可提高荧光激活细胞分选后用于定量 mRNA 的管内原位杂交的信噪比
DOI:
10.3109/10520295.2012.672650
发表时间:
2012
期刊:
Biotech Histochem
影响因子:
1.6
作者:
[Yamada, H., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.]
通讯作者:
T.
GITR遺伝子多型と自己免疫性甲状腺疾患の難治度・重症度との関連
GITR基因多态性与自身免疫性甲状腺疾病难治/严重程度的关系
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[武村和哉, 冨澤理恵, 2渡邉幹夫, 井上直哉, 早川和生, 赤水尚史, 日高洋, 岩谷良則]
通讯作者:
岩谷良則
Measuring TFF3/LGALS3 mRNA ratio in FNABS from thyroid nodule : a clinical trial of eighty cases.14th International Thyroid Congress (ITC), Paris, Sept.11-16, 2010
测量甲状腺结节 FNABS 中 TFF3/LGALS3 mRNA 比率:80 例临床试验。第 14 届国际甲状腺大会 (ITC),巴黎,2010 年 9 月 11-16 日
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamada, H., Takano, T., Kihara, M., Hirokawa, M., Yoshida, H., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A.]
通讯作者:
A.
自己免疫性甲状腺疾患の難治性・重症度とGITR遺伝子多型との関連
自身免疫性甲状腺疾病难治性/严重程度与GITR基因多态性的关系
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[冨澤理恵, 井上直哉, 渡邉幹夫, 赤水尚史, 早川和生, 岩谷良則]
通讯作者:
岩谷良則
Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-TSH receptor antibody.
TNFA 基因的功能多态性参与自身免疫性甲状腺疾病的发病机制和抗 TSH 受体抗体的产生。
DOI:
--
发表时间:
2009
期刊:
Clin Exp Immunol 156(2)
影响因子:
--
作者:
[Inoue, N., Watanabe, M., Nanba, T., Wada, M., Akamizu, T., Iwatani, Y.]
通讯作者:
Y.
共 39 条
Environmental factors influencing lifestyle-related diseases based on epigenomic information and clinical laboratory values of twins.
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批准号:19H04048
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.98万
-
财政年份:2019
-
负责人:WATANABE Mikio
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依托单位:
Rigorous analysis of epigenetic factors associating with the clinical course of diseases using discordant monozygotic twin pairs
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批准号:16H03261
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2016
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负责人:WATANABE Mikio
-
依托单位:
The continuations of medical philosophy and technology in changing social system of modern Japan.
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批准号:21590579
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2009
-
负责人:WATANABE Mikio
-
依托单位:
Manual making of investigation method for maintenance with a molecule marker
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批准号:14580587
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
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财政年份:2002
-
负责人:WATANABE Mikio
-
依托单位:
海外基金