A study of motilin-induced gastric migrating motor complex.-A novel approach for using newly established animal model-

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The suncus stomach and duodenum showed clear migrating phase III contractions(intervals of 80-150min)as found in humans and dogs. Exogenous motilin administration induced gastric phase III contractions, and motilin injection also increased the gastric motility index in a dose-dependent manner. Treatment of motilin antagonist inhibited the occurrence of phaseIII. Also, During the fasted state, cyclic MMC, consisting of phase I, II, and III were observed in both sham-operated and vagotomized suncus, but the duration and motility index(MI)of the phase II was significantly decreased in vagotomized suncus. In vagotomized suncus, feeing did not interrupt phase I of the MMC, and exogenous motilin induced strong phase III-like contractions as well as the fasted state.