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Role of innate immunity and influence of smoking in the Pathogenesis of alcoholic pancreatitis

Role of innate immunity and influence of smoking in the Pathogenesis of alcoholic pancreatitis
先天免疫的作用和吸烟在酒精性胰腺炎发病机制中的影响
批准号:
21590878
负责人:
NISHIO Akiyoshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To clarify the pathogenesis of alcoholic pancreatitis, we created a murine model induced by administration of ethanol and lipopolysaccharide and analyzed the role of innate and acquired immunity in the disease. Participation of acquired immunity was indispensable for the development of ethanol-induced pancreatitis. Smoking aggravated the disease. Induction of endogenous antioxidants ameliorated pancreatitis, suggesting the usefulness of antioxidant therapy for the treatment of alcoholic pancreatitis.
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会议论文
Autoimmune pancreatitis-a new evolving pancreatic disease?
自身免疫性胰腺炎——一种新发展的胰腺疾病?
DOI: --
发表时间: 2010
期刊: Langenbeck's archives of surgery.
影响因子: --
作者: [Okazaki K, et al.]
通讯作者: et al.
DOI: 10.1007/s00535-012-0564-5
发表时间: 2012-09
期刊: JOURNAL OF GASTROENTEROLOGY
影响因子: 6.3
作者: [Nakajima, Atsushi, Fukui, Toshiro, Takahashi, Yu, Kishimoto, Masanobu, Yamashina, Masao, Nakayama, Shinji, Sakaguchi, Yutaku, Yoshida, Katsunori, Uchida, Kazushige, Nishio, Akiyoshi, Yodoi, Junji, Okazaki, Kazuichi]
通讯作者: Okazaki, Kazuichi
マウスモデルを用いた自己免疫性膵炎発症における自然免疫の関与
使用小鼠模型研究先天免疫参与自身免疫性胰腺炎的发展
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Nakamichi I, Matsumoto T, Habtezion A, Omary MB, Iida M., 西尾彰功]
通讯作者: 西尾彰功
The role of innate immunity in the pathogenesis of alcoholic pancreatitis in mice
天然免疫在小鼠酒精性胰腺炎发病机制中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [青山友則, 池嶋健一, 今一義, 奥村京子, 渡辺純夫, Akiyoshi Nishio]
通讯作者: Akiyoshi Nishio
22
    Study on the role of regulatory B cells and their therapeutic application to acute and autoimmune pancreatitis
    • 批准号:
      15K09053
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2015
    • 负责人:
      NISHIO Akiyoshi
    • 依托单位:
    Role of innate immunity in the pathogenesis of autoimmune pancreatitis and analysis of its autoantigens
    Development of probiotics with antioxidant action for treatment of inflammatory bowel disease
    • 批准号:
      17590634
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      2005
    • 负责人:
      NISHIO Akiyoshi
    • 依托单位:
    海外基金