Development of the new therapy targeted for pancreatic cancer stem cell and cancer cells with EMT status via induction of cellular senescence

通过诱导细胞衰老开发针对胰腺癌干细胞和具有 EMT 状态的癌细胞的新疗法

• 批准号: 21590870
• 负责人: SATOH Kennichi
• 金额: $ 2.91万
• 依托单位: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所) (2011)Miyagi Cancer Center Research Institute (2010)Tohoku University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590870/
• 关键词: 膵癌; EMT; マイクロRNA; miR-126; ADAM9

The aim of this study was to identify the molecules to regulate EMT and the mechanism to control cellular senescence in pancreatic cancer. We revealed that miR 126 was down-regulated in invasive pancreatic cancer compared to non-invasive IPMN. In addition, the expression level of MSX2, inducer of EMT in pancreatic cancer, was found to be utilized for diagnosis of pancreatic cancer. Moreover, MSX2 expressing pancreatic cancer showed the chemoresistance, suggesting that EMT related molecules could be therapeutic target for pancreatic cancer.

本研究的目的是确定胰腺癌中调节EMT的分子和控制细胞衰老的机制。我们发现与非侵袭性IPMN相比，miR 126在侵袭性胰腺癌中表达下调。此外，胰腺癌中EMT的诱导物MSX2的表达水平也可用于胰腺癌的诊断。此外，表达MSX2的胰腺癌表现出化疗耐药，提示EMT相关分子可能成为胰腺癌的治疗靶点。

项目成果

The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2

• DOI: 10.1002/jcp.22781
• 发表时间: 2012-02-01
• 期刊: JOURNAL OF CELLULAR PHYSIOLOGY
• 影响因子: 5.6
• 作者: Hamada, Shin;Satoh, Kennichi;Shimosegawa, Tooru
• 通讯作者: Shimosegawa, Tooru

The expression level of MSX2 and S100P in brushing samples during ERCP differentiates pancreatic carcinoma from chronic pancreatitis

ERCP期间刷检样本中MSX2和S100P的表达水平可区分胰腺癌和慢性胰腺炎

• 发表时间: 2010
• 作者: Satoh K;Hamada S;Hirota M;Kanno A;Ito H;Shimosegawa T.
• 通讯作者: Shimosegawa T.

The evaluation of MSX2 mRNA expression level in biliary brush cytological specimens.

胆管刷状细胞学标本中MSX2 mRNA表达水平的评估。

• 发表时间: 2011
• 期刊: Anticancer Res. 31
• 作者: Ito H;Satoh K;Hamada S;Hirota M;Kanno A;Ishida K;Unno J;Masamune A;Katayose Y;Unno M;Shimosegawa T.
• 通讯作者: Shimosegawa T.

Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas

• DOI: 10.1007/s00535-010-0200-1
• 发表时间: 2010-07-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Satoh, Kennichi;Hamada, Shin;Shimosegawa, Tooru
• 通讯作者: Shimosegawa, Tooru

miR126の発現低下は膵癌細胞の浸潤を促進する

miR126表达减少促进胰腺癌细胞侵袭

• 发表时间: 2012
• 作者: 今一義;池嶋健一;青山友則;山形寿文;柳沼礼子;石川幸子;高島基樹;山科俊平;鈴木聡子;渡辺純夫;宮原良二;佐藤賢一
• 通讯作者: 佐藤賢一