Identification of the molecule binding with the cardiac transcriptional regulator HOP and analysis on the molecular function of heart failure

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HOP(Homeodomain-Only Protein) is a unique transcriptional regulator, which lacks DNA binding capacity but functions as the repressor of SRF-induced transcription. To identify the key molecule which could account for the functional consequences triggered by the HOP missense mutation identified previously in the patients with familial dilated cardiomyopathy, protein partner of HOP was screened using yeast 2-hybrid system in this study. Here I could identify 14 proteins which can bind with HOP. Identification of the molecular pathway linking with HOP will lead to the development of the novel therapeutic approach for heart failure.