Identification of effective agent against abdominal aortic aneurysm formation

鉴定抗腹主动脉瘤形成的有效药物

• 批准号: 25670380
• 负责人: MORITA Hiroyuki
• 金额: $ 2.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670380/
• 关键词: 大動脈瘤; ルテオリン; フラボノイド

The purpose of this study is to identify plant-derived agent having a protective effect on the abdominal aortic aneurysm formation, which can be orally administered for a long period. As a result, oral administration of luteolin, which is a widely distributed flavonoid found in many herbal extracts, was demonstrated to inhibit significantly the abdominal aortic aneurysm formation in the experimental model. Also, these effects were observed in a dose-dependent manner. Further studies are warranted to draw the clear conclusions on the more appropriate quantity and method for intake of this powerful flavonoid.

本研究的目的是确定对腹主动脉瘤形成具有保护作用的植物衍生剂，该药可长期口服。结果，口服木犀草素，这是一种广泛分布在许多草药提取物中的黄酮类化合物，在实验模型中被证明显著抑制腹主动脉瘤的形成。此外，这些影响是以剂量依赖的方式观察到的。需要进一步的研究，以得出明确的结论，更合适的数量和方法的摄取这种强大的黄酮类。

项目成果

Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous coronary intervention

接受经皮冠状动脉介入治疗的患者同时使用氯吡格雷或噻氯匹定和质子泵抑制剂相关的不良心血管结局

• 发表时间: 2013
• 期刊: Heart and Vessels
• 影响因子: 1.5
• 作者: Nakayama A;Morita H;Ando J;Fujita H;Ohtsu H;Nagai R
• 通讯作者: Nagai R

Human Genomics in Cardiovascular Medicine

心血管医学中的人类基因组学

• DOI: 10.1253/circj.cj-13-0126
• 发表时间: 2013
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Kimura K;Takenaka K;Ebihara A;Uno K;Morita H;Nakajima T;Ozawa T;Aida I;Yonemochi Y;Higuchi S;Motoyoshi Y;Mikata T;Uchida I;Ishihara T;Komori T;Kitao R;Nagata T;Takeda S;Yatomi Y;Nagai R;Komuro I;Morita H;森田啓行 ,山田奈美恵 ,小室一成;Morita H.
• 通讯作者: Morita H.

遺伝子から心筋症をみる

从基因看心肌病

• 发表时间: 2014
• 期刊: 日本内科学会雑誌
• 作者: Nakayama A;Morita H;Miyata T;Hoshina K;Nagayama M;Takanashi S;Sumiyoshi T;Komuro I;Nagai R.;森田啓行
• 通讯作者: 森田啓行

A novel channelopathy in pulmonary arterial hypertension.

• DOI: 10.1056/nejmoa1211097
• 发表时间: 2013-07-25
• 期刊: The New England journal of medicine
• 作者: Ma L;Roman-Campos D;Austin ED;Eyries M;Sampson KS;Soubrier F;Germain M;Trégouët DA;Borczuk A;Rosenzweig EB;Girerd B;Montani D;Humbert M;Loyd JE;Kass RS;Chung WK
• 通讯作者: Chung WK

M. Human genomics in cardiovascular medicine; implications and perspectives

M.心血管医学中的人类基因组学；

• 发表时间: 2013
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Nakayama A;Morita H;Miyata T;Hoshina K;Nagayama M;Takanashi S;Sumiyoshi T;Komuro I;Nagai R.;森田啓行;Morita H
• 通讯作者: Morita H