Cardiac remodeling and treatment due to brain-heart axis related with adiponectin expression in the heart

与心脏脂联素表达相关的脑心轴的心脏重塑和治疗

• 批准号: 21590941
• 负责人: KANDA Tsugiyasu
• 金额: $ 3.08万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590941/
• 关键词: BDNF; 肥満; 食事制限; ストレス; アディポネクチン; 心臓; 脳; サイトカイン; BDFN; 心筋傷害; 食餌制限

Brain-derived neurotrophic factor(BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. BDNF was originally isolated from the brain, but it is also expressed in the non-neural tissues. BDNF is expressed in cardiac muscle and may modulate cardiac function. Caloric restriction(CR) is beneficial for myocardial ischemia through BDNA signaling pathway. Moreover, CR in the obesity is improves myocardial damage and is closely related with the increase of hyppocampal BDNF mRNA. However, the relation between BDNF and heart disease is controversial. My data showed that cardiac and hyppocampal expression of BDNF can be induced by food restriction in obesity and that induced BDNF signaling can be beneficial in cardiac dysfunction. Moreover, physical activity became increased by CR after 3 months.

脑源性神经营养因子(BDNF)是神经营养因子家族中的一员，在脊椎动物的外周和中枢神经系统中具有重要的功能。BDNF最初是从大脑中分离出来的，但它也在非神经组织中表达。脑源性神经营养因子在心肌中表达，可能对心功能有调节作用。热量限制(CR)通过BDNA信号通路有利于心肌缺血的发生。此外，肥胖时CR可改善心肌损伤，并与下丘脑BDNF基因表达增加密切相关。然而，脑源性神经营养因子与心脏病之间的关系存在争议。我的数据显示，饮食限制可以诱导肥胖患者心脏和下丘脑中BDNF的表达，而诱导的BDNF信号转导可能有助于心功能障碍。此外，3个月后，CR使体力活动增加。

项目成果

A case report-Interleukin-6 expressing colon cancer with multiple hepatic metastasis

表达IL-6的结肠癌伴多发性肝转移1例报告

• 发表时间: 2011
• 期刊: J Kanazawa Med Univ
• 作者: Tenpaku A、Kanda T;(他11名、12番目)
• 通讯作者: (他11名、12番目)

Two types of Brugada-like ST-elevation in patients with febrile infection

发热感染患者两种类型的Brugada样ST段抬高

• 发表时间: 2011
• 期刊: J Kanazawa Med Univ
• 作者: Mizuno T、Kanda T;(他6名、7番目)
• 通讯作者: (他6名、7番目)

The effects of a PPARα agonist on myocardial damage in abese diabetic mice with heart failure

PPARα激动剂对肥胖糖尿病心力衰竭小鼠心肌损伤的影响

• 发表时间: 2010
• 期刊: Int Heart J
• 影响因子: 1.5
• 作者: 麹谷康子;金井恵理;Rui Chen
• 通讯作者: Rui Chen

Hormone therapy and blood pressure in postmenopausal women

绝经后妇女的激素治疗和血压

• DOI: 10.1016/j.jecm.2011.04.005
• 发表时间: 2011
• 期刊: Journal of Experimental and Clinical Medicine
• 作者: Sumino Hiroyuki;Ichikawa Shuichi;Kasama Shu;Takahashi Takashi;Kumakura Hisao;Takayama Yoshiaki;Minami Kazutomo;Kanda Tsugiyasu;Kurabayashi Masahiko;Murakami Masami
• 通讯作者: Murakami Masami

Restriction Induces Cardiac BDNF/TrkB Signaling and Improves Physical Activity in Obese Mice

限制诱导心脏 BDNF/TrkB 信号传导并改善肥胖小鼠的体力活动

• 发表时间: 2011
• 作者: Rui Chen、Kanda T;(他5名、6番目)
• 通讯作者: (他5名、6番目)