Imaging of intracellular dynamics of Ca^<2+>-influx-associated molecules and its physiological significance in endothelial cells.

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Intracellular Stim1 localization dynamically changes in response to Ca^<2+> store depletion and its expression level is linked to eNOS activation and NO production via regulation of Ca^<2+> influx level in cultured endothelial cells. We further analyzed endothelium specific Stim1 null mice and confirmed enhanced vascular contraction by phenylephrine, diminished endothelium-dependent vascular relaxation by acetylcholine, and elevation of blood pressure. Thus, Stim1 play a role in blood pressure regulation via eNOS/NO system and endothelial function.