Clarification of causal antigens of bronchial asthma in terms of cellular immune responses and mediators of bronchoconstriction

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Mechanism of bronchoconstriction in nonatopic asthma is studied in the present study. T cell IL-5 production was induced in response to house dust mite or mold allergens despite lack of IgE antibodies. Upon bronchial provocation, late asthmatic response, but not immediate asthmatic response, was induced in IL-5-producing asthmatics. To delineate mechanisms of IgE-independent bronchoconstriction, T cell clones were established, and the bronchoconstriction activity of activated T cell clones was analyzed in terms of human bronchial smooth muscle cells-embedded collagen gels.