Novel dendritic cell vaccine for tuberculosis with inhibition of indoleamine 2, 3-dioxygenase.

本研究旨在通过抑制吲哚胺2，3-双加氧酶（IDO）活性来开发一种新型的有效树突状细胞（DC）疫苗，用于细胞内病原体感染，如结核病。我们证明了用1-甲基-L-色氨酸（1 MT）处理降低了DC产生IL-10，导致其抗原呈递能力增强。此外，我们还发现血清IDO活性是社区获得性肺炎和肺结核的重要预后因素。

The present study was conducted to develop a novel potent dendritic cell(DC) vaccine by inhibiting indoleamine 2, 3-dioxygenase(IDO) activity for intracellular pathogen infections, such as tuberculosis. We demonstrated that treatment with 1-methyl-L-tryptophan(1MT) decreased IL-10 production from DCs, resulting in augmentation of their antigen-presenting capacity. In addition, we also showed that serum IDO activity is a significant prognostic factor in community-acquired pneumonia and pulmonary tuberculosis.