稳态增殖期间晚期肺癌的有效癌症免疫疗法-猫眼课题宝

稳态增殖期间晚期肺癌的有效癌症免疫疗法

批准号：

21590984

负责人：

WATANABE Satoshi

金额：

$2.5万

依托单位：

Niigata University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2009

资助国家：

日本

项目状态：

已结题

起止时间：

2009 至 2011

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590984/

关键词：

非閉塞性肺疾患癌肺線維症呼吸器感染症その他非特異的肺疾患癌抑制性T細胞化学療法 MDSC 腫瘍免疫療法抗腫瘍免疫療法放射線療法

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Previously, we found that radio-resistant Treg inhibited the development of antitumor immunity. In the current study, we also found that Treg was increased in cyclophosphamide treated mice. Depletion of Treg with anti-CD25 antibodies after cyclophosphamide treatment significantly augmented antitumor immune responses and eradicated advanced skin-tumors.CD25 is expressed on both of Treg and activated T cells. Anti-CD25 antibodies potentially deplete antitumor effector T cells. Thus, we have examined whether anti-TGF-b antibodies and anti-CTLA-4 antibodies efficiently deplete Treg in mice treated with cyclophosphamide.

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Henoch Schönlein purpura associated with pulmonary adenocarcinoma.

DOI： 10.1186/1752-1947-5-226

发表时间： 2011-06-22

期刊：

Journal of medical case reports

影响因子： 1

作者：

[Mifune D, Watanabe S, Kondo R, Wada Y, Moriyama H, Kagamu H, Yoshizawa H, Tetsuka T, Matsuyama A, Ito K, Narita I]

通讯作者： Narita I

IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis.

DOI： 10.1152/ajplung.00378.2011

发表时间： 2012-05

期刊：

American journal of physiology. Lung cellular and molecular physiology

影响因子： --

作者：

[T. Nei;S. Urano;N. Motoi;J. Takizawa;C. Kaneko;H. Kanazawa;R. Tazawa;K. Nakagaki;K. Akagawa;K. Akasaka;T. Ichiwata;A. Azuma;K. Nakata]

通讯作者： T. Nei;S. Urano;N. Motoi;J. Takizawa;C. Kaneko;H. Kanazawa;R. Tazawa;K. Nakagaki;K. Akagawa;K. Akasaka;T. Ichiwata;A. Azuma;K. Nakata

Successful treatment of advanced tumors with chemo-immunotherapy: a combination of cyclophosphamide and inhibition of chemo-resistant immune suppressor cells.

使用化学免疫疗法成功治疗晚期肿瘤：环磷酰胺与化疗耐药免疫抑制细胞的抑制相结合。

DOI： --

发表时间： 2012

期刊：

影响因子： --

作者：

[Yu Saida, Satoshi Watanabe, Tomohiro Tanaka, Junko Baba, Koichirou Nozaki, Kosuke Ichikawa, Jun Koshio, Satoru Miura, Junta Tanaka, Hiroshi Kagamu, Hirohisa Yoshizawa, Ichiei Narita]

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Efficacy and safety of sirolimus in lymphangioleiomymatosis

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DOI： --

发表时间： 2011

期刊：

N Engl J Med

影响因子： --

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[Hasegawa H, Inui N, Suda T, Shibata K, Nakamura Y, (他3名, 5番目), 中田光(他23名6番目)]

通讯作者：中田光(他23名6番目)

Class III beta-tubulin expression in tumor cells is correlated with resistance to docetaxel in patients with completely resected non-small-cell lung cancer.